45P - Debio 1143, an oral antagonist of inhibitor of apoptosis proteins, activates apoptosis and enhances radiosensitisation of non-small cell lung cancer...

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Basic Science
Lung and other Thoracic Tumours
Presenter Bo Lu
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors B. Lu
  • Rad Onc, Thomas Jefferson University, 19107 - Philadelphia/US

Abstract

Resistance to radiotherapy-induced apoptosis is a hallmark of cancer. Inhibitors of apoptosis proteins (IAPs) limit the effectiveness of radiation in non-small cell lung cancer (NSCLC). Debio 1143 (a.k.a AT-406) is an oral antagonist of multiple IAPs (cIAP1/2 and XIAP) currently in early clinical development. The purpose of this study was to investigate the potential of Debio 1143 as a radiosensitiser in NSCLC.