45P - Debio 1143, an oral antagonist of inhibitor of apoptosis proteins, activates apoptosis and enhances radiosensitisation of non-small cell lung cancer...
|Date||28 March 2014|
|Session||Lunch and poster display session|
|Topics|| Basic Science
Lung and other Thoracic Tumours
|Citation||Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131|
Resistance to radiotherapy-induced apoptosis is a hallmark of cancer. Inhibitors of apoptosis proteins (IAPs) limit the effectiveness of radiation in non-small cell lung cancer (NSCLC). Debio 1143 (a.k.a AT-406) is an oral antagonist of multiple IAPs (cIAP1/2 and XIAP) currently in early clinical development. The purpose of this study was to investigate the potential of Debio 1143 as a radiosensitiser in NSCLC.