20P - Correlation of carcinoembryonic antigen (CEA) with oxidative stress in carcinoma lung

Date 19 December 2015
Event ESMO Asia 2015 Congress
Session Poster presentation 1
Topics Lung and other Thoracic Tumours
Translational Research
Presenter Tania Sarkar
Citation Annals of Oncology (2015) 26 (suppl_9): 1-7. 10.1093/annonc/mdv517
Authors T. Sarkar1, P. Das1, S. Mukhopadhyay1, A. Chakraborty1, A. Mukhopadhyay2
  • 1Molecular Biology, Netaji Subhas Chandra Bose Cancer Research Institute, 700016 - Kolkata/IN
  • 2Hematology & Oncology, Netaji Subhas Chandra Bose Cancer Research Institute, 700016 - Kolkata/IN

Abstract

Aim/Background

Tumor markers are not only of significance to the researcher in understanding tumor biology, but also to the clinician in treating patients with cancer. The aim of this study was to determine diagnostic relationship between levels of serum CEA and oxidative stress markers in carcinoma lung. It also focuses to analyse clinical response of antioxidants in patients with lung cancer undergoing advanced chemotherapy.

Methods

6ml of blood samples were collected from each of 81 Lung cancer patients (age range between 32 to 65 years), attending the outpatient department of our institute and 43 age and sex matched randomly selected normal persons. Measurement of total oxidant level (TOS), total antioxidant level (TAS), lipid peroxidation by TBARS assay, glutathion level (GSH), free reactive iron level and serum CEA level were estimated in patients as well as normal control.

Results

From the analysis of 43 normal persons and 81 lung cancer patients, we observed mean TOS, TAS, TBARS/MDA, FRI values and CEA level. The student's t-test showed significant differences between the carcinoma lung and normal controls in CEA, and oxidative stress markers. Moreover, Pearson's correlation coefficient (r) indicated significant correlations between CEA and MDA.

Conclusions

In this study we confirmed the CEA influence with components of lung carcinogenesis. We found correlation between Lipid peroxidation and CEA among the patients in comparison to control subjects. From our study, we can conclude the following points which may indicate the evaluation of disease pathogenesis in lung cancer.We may consider those biochemical parameters as the Biomarkers in the prognosis and secondary disease pathogenesis of Lung carcinoma. High-dose chemotherapy is associated with increased formation of reactive oxygen species and depletion of critical antioxidants. In high-dose chemotherapy, the plasma antioxidant concentration has been shown to decrease. So application of chemotherapy along with common antioxidants like vitamin C, vitamin E may be beneficial to fight with the increased level of free radicals.

Clinical trial identification

N.A

Disclosure

All authors have declared no conflicts of interest.