170P - Anterior mediastinal mass case series

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Lung and other Thoracic Tumours
Presenter Palaniappan Ramanathan
Citation Annals of Oncology (2015) 26 (suppl_1): 51-54. 10.1093/annonc/mdv053
Authors P. Ramanathan, P. Shivanna, S. Kumar, D. Pandey, S.V.S. Deo, N.K. Shukla
  • Surgical Oncology, All India Institute of Medical Sciences, 110029 - New Delhi/IN

Abstract

Aim/Background

To study the clinical features, different histology, treatment patterns and outcomes of anterior mediastinal masses in a developing thoracic oncology institute.

Methods

Retrospective analysis of thoracic surgery database maintained in the department of surgical oncology, BRA IRCH, AIIMS, New Delhi, India was analyzed from 2013 to 2014. Surgically explored anterior mediastinal mass patients were included in the study.

Results

A total of 11 cases were diagnosed to have anterior mediastinal mass contributing to 0.1% of all malignancies. Median age of presentation is 40 years [6 to 62 years] with a male predominance [M:F = 7:4]. Chief complaints were chest pain and cough. Computed tomography was done in all patients and pre operative biopsy / needle aspiration done for diagnosis in majority. Five patients were diagnosed to have thymoma with three myasthenia gravis features, two cases of germ cell tumor and poorly differentiated carcinoma and inflammatory myofibroblast tumor each. Four patients received neoadjuvant chemotherapy [two cases of germ cell tumor and two cases of locally advanced thymoma] and yielded a partial response. Median sternotomy done in 10 cases and R 0 resection achieved in 10 patients. Phrenic nerve, pericardium, pleura, lung, manubrium, superior vena cava and brachiocephalic vein were the surrounding structures involved. Histopathology showed majority to be thymoma [six patients; WHO AB- 1, B1–2, B2–2, B3–1] followed by germ cell tumor – 3 patients [rare – seminoma in female], one each in adenomatous goiter of thyroid and inflammatory myofibroblast tumor. Six patients received adjuvant therapy and all myasthenia gravis patients showed symptomatic improvement.

Conclusions

Multimodality management with aggressive surgery results in better outcomes of anterior mediastinal mass.

Disclosure

All authors have declared no conflicts of interest.