21P - Alteration of tumor suppressor genes in malignant pleural effusion

Date 28 March 2014
Event ELCC 2014
Session Lunch and poster display session
Topics Lung and other Thoracic Tumours
Pathology/Molecular Biology
Translational Research
Presenter Junghyun Chang
Citation Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131
Authors J. Chang
  • Respiratory Center, Ewha Womans University, 158710 - Seoul/KR


Pleural fluid is one of the most important materials for cancer diagnosis. Although cytologic examination has been used as a standard method to diagnose malignant effusion, its sensitivity is still insufficient. To determine whether the genetic analysis of pleural fluid can be used for the diagnosis of malignant effusion, mutations of p53 and FHIT, loss of heterozygosity (LOH), and microsatellite instability (MA) were investigated in malignant pleural effusion.