466P - Adenoid cystic carcinoma of the trachea and bronchus: prognostic factors and patterns of recurrence

Date 20 December 2015
Event ESMO Asia 2015 Congress
Session Poster presentation 2
Topics Lung and other Thoracic Tumours
Translational Research
Presenter Mian Xie
Citation Annals of Oncology (2015) 26 (suppl_9): 125-147. 10.1093/annonc/mdv532
Authors M. Xie
  • Guangzhou Institute Of Respiratory Disease, The 1st Affiliated Hospital of Guangzhou Medical University, 510100 - Guangzhou/CN

Abstract

Aim/Background

Adenoid cystic carcinoma (ACC) of the trachea and bronchus are rare primary bronchopulmonary carcinomas with low malignancy. The prognostic factors ACC are undefined.

Methods

217 ACC tumors operated between May 1988 and March 2012 were collected from a cooperative multicenter group in China. We studied clinical and pathological features in these tumors, analyzing prognostic significance and patterns of recurrence. Survival analysis data were collected from a systematic follow-up database. Statistical analyses were carried out using a SPSS V.19.0 statistical package.

Results

Five-year and 10-year survival were excellent, 71% and 51% respectively. Sixty of patients (27.6%) had local recurrence 161 ± 29 (range 130 to 191) months after surgery. Distance metastases ocurred after a median interval of 87 ± 56 (range 28 to 146) months after surgery. In a univariable analysis, male (P = 0.02), bronchial AAC (P = 0.002), tubular subtype (P = 0.01), postoperative radiation (P < 0.001) presented statistically significant differences related to survival of these patients. In multivariable analysis, only postoperative radiation was an independent risk factor for survival (P < 0.001; HR: 0.56). Regarding to recurrence factors in a univariable analysis, tubular subtype (P = 0.02) and postoperative radiation (P = 0.008) were associated with locoregional recurrence. Patients with bronchial AAC presented higher frequencies of distant recurrence (P = 0.003). In a multivariable analysis, postoperative radiation was an independent prognostic factor to predict logoregional recurrence (P < 0.001; HR: 0.62).

Conclusions

The long-term outcome was poor due to late local recurrences and late metastatic spread. Complete standard surgical resection is essential for ACC. Conservative excision without postoperative irradiation with advanced lesions are related to logoregional recurrence.

Clinical trial identification

NO.

Disclosure

All authors have declared no conflicts of interest.