25P - A common BIM deletion polymorphism was associated with the risk of lung cancer in a Chinese population

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Cancer Aetiology, Epidemiology, Prevention
Lung and other Thoracic Tumours
Presenter Xia Jing
Citation Annals of Oncology (2015) 26 (suppl_1): 6-9. 10.1093/annonc/mdv044
Authors X.J. Jing
  • Respiratory Department, Shanghai Chest Hospital, 20030 - Shanghai/CN

Abstract

Aim/Background

The deletion polymorphism could lead to similar effect as low expression level of BIM. Hence, we aimed to study the potential association between the deletion polymorphism and the risk of lung cancer.

Methods

We enrolled 5698 participants in the present study, including 2640 cancer patients and 118 carcinoid tumor patients. χ2 test or Fisher's exact test were utilized in the association analysis between the deletion polymorphism and participants' characteristics. The associations between the deletion polymorphism and lung cancer were analyzed with logistic regression model.

Results

In the present study, the people carrying the deletion polymorphism showed higher risk of SCLC (P = 0.028, OR = 1.64; 95% CI, 1.04-2.53), especially in smokers (P = 0.042, OR = 1.72; 95% CI, 1.01-2.90) and elderly people (P = 0.003, OR = 3.10; 95% CI, 1.42-6.49), while they showed lower risk of adenosquamocarcinoma or large cell lung cancer (P = 0.024, OR = 0.45; 95% CI, 0.21-0.87). We also indentified that the deletion polymorphism was significantly associated with the risk of squamous cell carcinoma in elderly people (P = 0.033, OR = 2.02; 95% CI, 1.04-3.78).

Conclusions

In conclusion, the 2903-bp deletion polymorphism of BIM was correlated with the risk of lung cancer.

Disclosure

The author has declared no conflicts of interest.