286P - Prognostic and predictive values of BI-RADS classification in breast cancer patients

Date 01 October 2012
Event ESMO Congress 2012
Session Poster presentation III
Topics Breast Cancer, Early Stage
Imaging, Diagnosis and Staging
Presenter Yao-Lung Kuo
Authors Y. Kuo1, L. Cheng2, T. Chang1
  • 1Surgery, National Cheng Kung University, 704 - Tainan/TW
  • 2Radiology, National Cheng Kung University, 704 - Tainan/TW

Abstract

Objective

The goal of this study is to determine the prognostic and predictive values of the Breast Imaging Reporting and Data System (BI-RADS) classification in breast cancer patients.

Patients and methods

1045 patients with breast cancer were disgnosed between January 1, 1999, and December 31, 2007, and 512 (48.9%) of them were classified as BI-RADS 5. Overall survival and disease-free survival were estimated with the Kaplan-Meier method and compared across the two groups (BI-RADS 5 versus BI-RADS 0-4) using the log-rank test. Univariate and multivariate analyses were used to identify the prognostic factors.

Results

The median follow-up time was 87.8 months. Laplan-Meier analysis showed a significant difference between the two subgroups in five-year overall survival (p < 0.0001) and five-year disease-free survival (p < 0.0001). On multivariate analysis, the BI-RADS mammographic findings, lymph node status, HER-2 status, and tumor grade were significant factors related to five-year overall survival and disease-free survival.

Conclusion

The BI-RADS classification is a reliable prognostic and predictive factor. Taiwanese breast cancer patients with BI-RADS 5 mammographic finding showed a higher relapse rate than patients with BI-RADS 0-4 mammographic finding.

Disclosure

All authors have declared no conflicts of interest.