84P - 3D MRI for quantitative analysis of quadrant percent breast density (QPD): Correlation with quadrant location of breast cancer

Date 07 May 2015
Event IMPAKT 2015
Session Welcome reception and Poster Walk
Topics Breast Cancer
Imaging, Diagnosis and Staging
Presenter Jeon-Hor Chen
Citation Annals of Oncology (2015) 26 (suppl_3): 27-28. 10.1093/annonc/mdv119
Authors J. Chen1, Y. Li2, M. Su2
  • 1Radiology, Eda Hospital and I-Shou University, Kaohsiung/TW
  • 2Radiology, Chao Family Comprehensive Cancer Center, Irvine/US



Purpose: This study developed a new quantitative method based on magnetic resonance imaging (MRI) to measure quadrant percent breast density (QPD) in the contralateral normal breast and to correlate with the quadrant location of the breast cancer in the diseased breast.

Methods: One hundred and eighteen women, including 77 Asian women and 41 western women, with unilateral breast cancer, which had clear quadrant location, were studied. The quadrant location of the cancer was assigned by an experienced radiologist by reviewing the dynamic contrast enhanced (DCE) MR images. The contralateral normal breast was segmented and quantified for its overall percent breast density (PD) using a well-developed automatic algorithm. Based on the segmented three-dimensional (3D) image, QPD in each quadrant was further analyzed using the nipple as the anatomic landmark. The orientation of the breast was corrected based on the centriod. The distribution of breast cancer, highest QPD, and lesions arising from the highest QPD in the different quadrants were analyzed in the whole cohort and compared between the two subject groups.

Results: Overall, breast cancer grew more commonly from the outer upper quadrant (39/118, 33.1%) than the other three quadrants. The highest QPD was also noted most frequently in the outer upper quadrant (41/118, 34.7%). When correlating the highest QPD with the quadrant location of breast cancer, only 29 women (29/118, 24.6%) had breast cancer occurring in the quadrant with the highest QPD. Asian women tended to have the highest QPD in the outer lower quadrant (26/77, 33.8%), different from the Western women noted in the outer upper quadrant (21/41, 51.2%).

Conclusion: This was the first report using MRI to quantify quadrant breast density in the normal breast. The results from this study noted a higher proportion of women with breast cancer in the outer upper quadrant. The outer upper quadrant also showed higher frequency of the highest QPD among the four quadrants in the western women but not in the Asian women. Our results also noted that the quadrant preference of breast cancer could not be fully explained by the larger amount of breast tissue alone in that specific quadrant.

Disclosure: All authors have declared no conflicts of interest.