1025P - The significance of primary tumor volume and EBV on survival and recurrence in pediatric patients with nasopharyngeal carcinoma

Date 29 September 2014
Event ESMO 2014
Session Poster Display session
Topics Cancer in Special Situations
Head and Neck Cancers
Presenter Soha Ahmed
Citation Annals of Oncology (2014) 25 (suppl_4): iv340-iv356. 10.1093/annonc/mdu340
Authors S.A. Ahmed1, E. Eldebawy1, H. Ammar1, A. El Nashar1, M.S. Zaghloul2
  • 1Radiotherapy Department, Children's Cancer Hospital Egypt, 11441 - Cairo/EG
  • 2Radiotherapy Department, Children's Cancer Hospital, Cairo/EG

Abstract

Aim

Primary tumor volume (PTV) has been recognized as a promising prognostic indicator in the treatment of adult nasopharyngeal carcinoma (NPC). Our study was designed to analyze the value of the primary tumor volume [gross tumor volume of the primary site (GTV-P)] and EBV association in predicting the treatment outcome in pediatric patients with NPC treated with intensity modulated radiotherapy (IMRT).

Methods

A retrospective review of 30 consecutive pediatric patients aged <18 years with stage I–IVB NPC was performed. All Patients received three cycles of Induction chemotherapy with cisplatin and 5-fluorouracil, and three additional cycles of cisplatin alone during radiation therapy. Radiation therapy was administered using IMRT technique and inverse planning system. Gross tumor volume of primary tumor plus retropharyngeal nodes (GTVprn) was calculated to be an index of treatment outcome.

Results

The median PTV was 45.9ml. Large GTVprn (>55 ml) was associated with a significantly poorer local control, lower distant metastasis-free rate, and poorer survival. 3-year overall survival in the large tumor volume group (>55 ml) and the small tumor volume (≤ 55ml) were 58% and 100%, respectively (p = 0.007).The 3-year disease-free survival was 28% in the large tumor group and 94% in small tumor volume group (p = 0.002) while 3 year local recurrence-free survival in the large tumor group was 77% and 100% in the small tumor volume group (p = 0.02).The 3-year overall survival, disease-free survival, local control, and distant metastasis-free rates in all patients were 87%, 76%, 92%, and 76%, respectively.

Conclusions

PTV had a close relationship with survival rates and recurrence rates in pediatric patients with NPC. The large tumor volume group (PTV > 55 ml) was associated with more recurrence and poor survival rate.

Disclosure

All authors have declared no conflicts of interest.