1017P - The effect of preoperative chemotherapy with S-1 alone for oral squamous cell carcinoma patients

Date 29 September 2014
Event ESMO 2014
Session Poster Display session
Topics Anti-Cancer Agents & Biologic Therapy
Head and Neck Cancers
Presenter Mitsuhiro Nakazawa
Citation Annals of Oncology (2014) 25 (suppl_4): iv340-iv356. 10.1093/annonc/mdu340
Authors M. Nakazawa1, T. Imai1, I. Kato1, M. Ohmae2, T. Sumi1, A. Niki1, M. Suematsu3, Y. Matsumoto3, K. Amino4
  • 1Oral & Maxillofacial Surgery, Osaka University, 565-0871 - Suita/JP
  • 2Oral & Maxillofacial Surgery, Rinku General Medical Center, 598-8577 - Izumisano/JP
  • 3Oral & Maxillofacial Surgery, Meiwa Hospital, 663-8186 - Nishinomiya/JP
  • 4Oral & Maxillofacial Surgery, Nishinomiya Municipal Central Hospital, 663-8014 - Nishinomiya/JP

Abstract

Aim

We carried out S-1 monotherapy for oral squamous cell carcinoma (OSCC) patients during the period between histological diagnosis and surgery. The object of this therapy is to inhibit progression of disease until definitive surgery, but many cases obtained good response being better than PR. We retrospectively investigated the antitumor effect and adverse effects of preoperative S-1 monotherapy for OSCC.

NC PR CR
local recurrence 13.6 9.1 4.2
regional metastasis 18.6 18.2 0%

Methods

105 fresh cases with stage I-IV OSCC patients were enrolled in this study. Patients consisted of T1:26, T2:64, T3:7 and T4:8 cases. S-1 was administerd at 80mg/m2/day by a regimen of two-week application and one-week rest, and followed by definitive surgery. Clinical response was examined by clinical findings and/or CT, and histological effects were evaluated with surgical specimens.

Results

Median administration period was 14 days (2-56 days), and median total dosage was 1680 mg (160-6720mg). The histological response rate was 43.8% and CR rate was 20.9%. The response rate including CR + PR (CR rate) by T stage was T1:46.2(26.9), T2:45.3(23.4), T3:57.2(14.3) and T4:12.5(12.5)%. 98 patients accepted definitive surgery, but 7 patients who obtained clinical CR accepted only biopsy. The rate of local recurrences and late regional lymph node metastases according to chemotherapy effect was as follows for at least 2 years follow-up.

Local and regional recurrence rate was 0% in T1/2 cases. There was a tendency that effective cases showed good prognosis in T3/4 cases. Toxicities more than grade 3 were not observed, and did not prevent subsequent surgery.

Conclusions

Preoperative S-1 monotherapy was useful for OSCC patients, especially T1/2 cases, because of effective antitumor activity and acceptable toxicity. Effective cases showed good prognosis.

Disclosure

All authors have declared no conflicts of interest.