1059 - Anti oxidant capacity of calendula officinalis flowers extract and prevention of radiation induced oropharyngeal mucositis in patients with head and...
|Date||28 September 2012|
|Event||ESMO Congress 2012|
|Topics|| Supportive Care
Head and Neck Cancers
D. Moslemi1, N. Babaee2, A. Moghaddamnia3, G. Mazdai4
To determine the effect of Calendula officinalis flower extract mouthwash as gel formulation on radiation-induced oropharyngeal mucositis (OM) in patients with head-and-neck cancer. Forty patients with neck and head cancers who were treated with radiotherapy or chemoradiotherapy were randomly assigned to receive either 2% calendula extract mouthwash or placebo (20 patients in each group). The subjects were treated with telecobalt radiotherapy at conventional fractionation (2 Gy/fraction, five fractions weekly, 20–35 fractions within 4–7 weeks). Oropharyngeal mucositis was evaluated by two doctors (a radiation oncologist and a dentist), using the oral mucositis assessment scale (OMAS). The patients also received concurrent chemotherapy. Calendula mouthwash significantly decreased the intensity of OM compared to placebo at week 2 (score: 5.5 vs. 6.8, p = 0.019), week 3 (score: 8.25 vs. 10.95, p < 0.0001) and week 6 (score: 11.4 vs. 13.35, p = 0.031). Total antioxidant, polyphenol and flavonoid contents and quercetin concentration of the 1% extract were 2353.4 ± 56.5 µM, 76.66 ± 23.24, 313.40 ± 6.52 mg/g and 19.41 ± 4.34 mg/l, respectively. Calendula extract gel could be effective on decreasing the intensity of radiotherapy- induced OM during the treatment and antioxidant capacitiy may be partly responsibe for the effect.Disclosure
All authors have declared no conflicts of interest.