861P - Multicentre UK experience of sex cord stromal tumours

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Germ Cell Tumours
Presenter Rebecca Lee
Citation Annals of Oncology (2014) 25 (suppl_4): iv280-iv304. 10.1093/annonc/mdu337
Authors R. Lee1, W. Appel2, M. Leahy1, A.J. Birtle2
  • 1Medical Oncology, The Christie NHS Foundation Trust, m20 4bx - manchester/GB
  • 2Rosemere Cancer Centre, Lancashire Teaching Hospitals NHS Foundation Trust, PR2 9HT - Preston/GB



Sex cord stromal tumours account for approximately 5% of testicular tumours. The majority behave benignly and require no adjuvant treatment once excised. However 10-15% behave more aggressively and tend to respond poorly to standard treatments for other testicular tumours. Due to their rarity, few series are published regarding their features, behaviour and management including follow up strategies. In one of the largest series of sex cord stromal tumours to be reported we aim to review their features and evaluate our current management and follow up.


We conducted a retrospective review of patients presenting with sex cord stromal tumours between 2006 and 2013. Cases were identified through the North West supraregional testicular cancer network records. Patients were referred to multiple sites throughout the North West and their path pathology, clinical features and outcomes were assessed.


We identified 28 patients; 5 of whom were diagnosed with sertoli tumours and 23 with leydig tumours. Median age at diagnosis was 41 years and 4 patients had a previous history of orchidopexy. The median size of tumours was 6 mm and all were staged as T1N0M0 at presentation. Only occasional mitoses were seen, none had vascular invasion or necrosis and in the 8 patients with recorded MIB1 expression this was <3%. All had a negative tumour markers and a normal lactate dehydrogenase. There have been no recurrences of disease.


Our data supports our current policy to review patients every 4 months with a CT restaging scan at 1 year and to discharge if there are no concerning features.


All authors have declared no conflicts of interest.