P-0089 - Transient elastography (FibroScan®) – predictor of hepatocellular carcinoma prognosis in patients referred to surgical treatment

Date 28 June 2014
Event World GI 2014
Session Poster Session
Topics Gastrointestinal Cancers
Imaging, Diagnosis and Staging
Presenter Iulia Suceveanu Andra
Citation Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165
Authors I. Suceveanu Andra1, I. Parepa2, D. Catrinoiu3, D. Tofolean3, F. Voinea3, L. Mazilu4, P. Suceveanu Adrian5
  • 1Ovidius University, Emergency Hospital, Constanta County, Constanta/RO
  • 2Clinical Hospital of Emergency, Ovidius University of Constanta, Constanta/RO
  • 3Ovidius University Constanta, Constanta/RO
  • 4Clinical Emergency Hospital, Ovidius University of Constanta, Constanta/RO
  • 5Ovidius University, Emergency Hospital, Constanta/RO

Abstract

Introduction

The prognosis of hepatocellular carcinoma (HCC) after surgical treatment depends on multiple factors. The portal hypertension and the underlying score of liver fibrosis are the main features involved in prognosis after surgical treatment. This study aims to investigate the role of transient elastography (FibroScan®) as a predictor of HCC outcome and prognosis in patients referred to surgical therapy.

Methods

The study was conducted in Gastroenterology and Oncology Departments of St. Andrew Emergency Hospital of Constanta County where were diagnosed and followed-up 108 patients with HCC occurred on liver cirrhosis surgically treated. The enrollment period was 2007-2012. The mean follow-up period was 29 months + /- 23 days. The liver function was assessed according to Child-Pugh classification. Before referring the patients to surgery, all of them were investigated regarding the liver stiffness (LS) using the FibroScan(®). We calculated the correlation between the results of the LS in FibroScan and the overall cumulative survival rates.

Results

The male/female ratio was 3.5/1. The mean age of enrolled patients was 63.8 years. The main etiology of disease was HBV followed by HCV, alcohol and co-infection HBV + HDV related cirrhosis. The Child Pugh Classification splat our patients in 3 categories: A – 58 patients (53.70), B – 31 patients (28.70) and C–19 patients (17.59). Our statistical analyses revealed that the cumulative 1-, 3-, and 5-year disease-free survival rates were 47%, 33%, and 19% for the values of LS less than 19.4, 38%, 27% respectively 16% for patients with the LS between 19.4 and 25.2kPa, respectively 26%, 18% respectively 11% for patients with the LS between 25.2 and 31kPa, with p values significantly different between our results (p < 0.05). We demonstrated that the cut-off values of 19.4, 25.2 and 31 kPa could be used as prognostic factors for the survival rates in patients with HCC referred to surgical treatment.

Conclusion

In conclusion, the transient elastography (FibroScan®) measuring the LS looks a simple method to predict the outcome and prognosis of patients with hepatocellular carcinoma referred to surgical therapy.