P-280 - Reduction effect of Oxaliplatin-Related sensory neurotoxicity by Goshajinkigan (TJ-107) plus Powdered processed aconite root (TJ-3023)

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Anti-Cancer Agents & Biologic Therapy
Complications of Treatment
Supportive Care
Gastrointestinal Cancers
Presenter Y. Shindo
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors Y. Shindo, T. Yoshida
  • Nakadori General Hospital, Akita/JP

Abstract

Introduction

FOLFOX and CapeOX is one of standard therapies for advanced-stage colorectal cancer. Sensory neurotoxicity (SN) with oxaliplatin is its dose-limiting toxicity. We decided to use goshajinkigan (TJ-107) for prevention of oxaliplatin-related SN.

We think that the main action is the one with powdered processed aconite root (TJ-3023).

Methods

The subjects were 110 patients with advanced-stage colorectal cancer. All 110 patients take TJ-107 (7.5g/day) every day from first oxaliplatin infusion day. Patients profiles were: Male/Female: 57/53, median age 69 years old (38 ∼ 84), PS0/1/2/3: 79/31/0/0, clinical stage IIIC/IV: 14/96. Oxaliplatin (85mg/m2) was given as FOLFOX4 (27cases), mFOLFOX6 (83cases). When SN was increased, TJ-3023 was added to 32 patients. TJ-3023 is one of ingredients of TJ-107.

Results

Total course numbers of FOLFOX were1323, and average number of FOLFOX was 12.01. Relative dose intensity of oxaliplatin was 38.8mg/m2/week. Medicine compliance of TJ-107 was 89%. 41 patients had grade 3 toxicity (neutropenia 31, thrombocytopenia 10). TTP is 8.23 months. Response Evaluation Criteria is CR/PR/SD/PD/NE:5/59/15/5/26. SN occurred in 70 patients (63.6%). TJ-3023 was added to 32 patients. SN was slightly decreased by TJ-3023. There was no neurotoxicity case with functional impairment in this study.

Conclusion

TJ-107 seems to prevent acute oxaliplatin-induced SN. TJ-3023 may be related to SN prevention mechanism. The continuance of chemotherapy for colorectal cancer can be expected by these Kampo medicines (TJ-107 & TJ-3023).