P-341 - Prognostic factors and local recurrence on patients with rectal carcinoma

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Rectal Cancer
Pathology/Molecular Biology
Presenter A. Simsek
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors A. Simsek, N. Zeybek, T. Ozer, N. Ersoz, Y. Peker
  • Gulhane Military Medical Academy, Ankara/TR

Abstract

Introduction

Despite technical refinements such as complete excision of the mesorectum and wider lateral resection margins, the risk of local recurrence after resection of rectal cancer remains a constant dilemma.

The aim of the study was to evaluate and compare some prognostic factors and local recurrences for rectal cancer.

Methods

A retrospective review of 140 patients with rectal cancer operated on at Gulhane Military Medical Academy between 2008 and 2015 was conducted. We have studied histologic type, histologic grade, vascular and perineural invasion. Although we studied 5 years survival, we determined staging is the most meaningful indicator related with prognosis.

Results

Variables recorded, including age, gender, location, stage, histopathologic differentiation of the tumor and type of curative operation. Of the patients 98(70%)were males and 42(30%)were females. Mean age was 66.2, range 20 to 89. Overall recurrences were detected in 28(20%) of cases. All of local recurrences were found in stage III patients according to TNM classification. Localization of tumor, type of the curative operations and degree of histopathologic differentiation did not have significant effect for occurrence of local recurrences. All local recurrences occurred in the first two years after the curative operation and local recurrence was one of the leading causes for mortality. We found that whose tumors demonstrate vascular invasion appear to have a shorter survival but this finding usually accompanies which advanced stage of disease. Unless never methods of assessing the biological behavior of rectal cancers can be shown to provide information otherwise available, careful clinical radiologic, and pathologic evaluations will remain paramount on ensuring the best possible outcome for patients

Conclusion

Oncological outcome is still the most important factor, and tumor recurrence leads to a strong impairment of quality of life. Current efforts to prevent local recurrence in patients with transmural extension or regional lymph node involvement include combined pre and postoperative radiation and chemotherapy.