161P - Is S-1/oxaliplatin with bevacizumab able to be an alternative chemotherapy against advanced/metastatic colorectal cancer?

Date 19 December 2015
Event ESMO Asia 2015 Congress
Session Poster presentation 1
Topics Anti-Cancer Agents & Biologic Therapy
Colon Cancer
Rectal Cancer
Presenter Hiroshi Osawa
Citation Annals of Oncology (2015) 26 (suppl_9): 42-70. 10.1093/annonc/mdv523
Authors H. Osawa
  • Oncology And Hematology, EDOGAWA HOSPITAL, 133-0052 - TOKYO/JP

Abstract

Aim/Background

Chemotherapy with S-1 and oxaliplatin plus bevacizumab (B-SOX) is a new treatment for advanced or metastatic colorectal cancer. SOFT strial proved B-SOX which is non-inferior to mFOLFOX6 plus Bmab with respect to progression free survival as first-line chemotherapy for advanced or metastatic colorectal cancer. In contrast, there has been few reports on an efficacy and safety of combination chemotherapy as B-SOX in clinical situation. We aimed to recognize whether B-SOX is able to be an alternative first line chemotherapy against advanced or metastatic colorectal cancer in clinical situation or not.

Methods

This trial was retrospective trial. There were 60 advanced or metastatic colorectal patients enrolled. Treatment regimen; Bmab (7.5kg/kg) and L-OHP (130mg/m2) were administrated intravenously on day 1, while S-1 was administrated orally (80 mg/m2/day, twice a day) for 14-days followed by a 7-days break. Eligibility criteria. 1:histrogically proven colorectal adenocarcinoma, 2:ECOG PS score: 0–2, 3:presence of assessable lesions as confirmed by CT or MRI, 4:no previous chemotherapy or radiotherapy, 5:1) no age restrictions; 2) major organ function preserved; 3) no active multiple primary cancers seen; 4) recovered from postoperative complications; 5) no serious complications (intestinal obstruction, diarrhea, fever); 6) able to begin within 4–8 weeks after surgery; 7) provided written consent based on informed consent. Primary endpoints were best overall response and disease control rate, secoundary endpoints was safety.

Results

Patients Characteristics No. of Patients(N = 60)
Gender male/Female 37/23
Age Median/Range 68/51-79 year
Primary Colon/Retal/Colorectal 31/22/7
Primary resection Yes/No 43/17
PS 0/1/2 21/29/10
Metastatic site Liver/Lung/LNs/Others 37/26/21/8
Best overall response CR/PR/SD/PD 0/50/8/2
Disease contorol rete CR + PR + SD 96.7%
PFS Median 10.6 months

Conclusions

In this study, SOX + BV chemotherapy showed tolerable toxicities and non-inferior response rate and diseases control to mFOLFOX6 + Bmab. And our result was similar PFS compare to SOFT trial. B-SOX chemotherapy is seemed to be valid choice for ambulatory chemotherapy.

Clinical trial identification

Investigator initiated trials

Disclosure

All authors have declared no conflicts of interest.