P-159 - Gastric myoelectric activity disturbances in patients with gastric and colorectal cancer. Preliminary study

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Gastric Cancer
Colon Cancer
Rectal Cancer
Presenter A. Zygulska
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors A. Zygulska1, A. Furgala2, K. Krzemieniecki3, P. Thor4
  • 1University Hospital, Krakow/PL
  • 2Department of Pathophysiology Medical College Jagiellonian University, Krakow/PL
  • 3Oncological Department Collegium Medicum Jagiellonian University, Krakow/PL
  • 4Department of Pathophysiology Medical College of Jagiellonian University, Krakow/PL

Abstract

Introduction

The gastric myoelectrical activity recording provides information about both fasting, as well as fed gastric motor function. Delayed gastric emptying is linked with changes in EGG: a lower percentage of normal gastric slow waves and a lower postprandial increase in dominant power (DP) of EGG. Investigation of the relationship among motility disorders and dyspeptic symptoms in patients with gastric and colorectal cancer has been very seldom so far.

Purpose of this paper is the evaluation of disturbances in gastric myoelectric activity and correlation they with dyspeptic symptoms in patients with gastric and colorectal cancer.

Methods

Fourteen patients (out of planned 90) with gastric or colorectal cancer and 30 healthy persons were enrolled to this study. Every patient underwent surgical operation due to gastric or colorectal cancer. Surface cutaneous electrogastrography (EGG) was performed by 4-channels Polygram NET (Medtronic, Denmark) and were measured in fasted and fed subjects. Patient characteristics are presented in table 1.

Results

EGG was abnormal in 12 studied patients. Fasting patients showed decreased percent time of normogastria (52.8 + /-24.5 vs. 82 + /-12.3%, p = 0.02) and slow wave coupling (SWC) (61.1 + /-17 vs. 67 + /-18, p = 0.01) with increased dominant power (DP) (13.3 + /-1 vs. 11.1 + /-1.1, p = 0.0001). In fed patients:% of normogastria, DP, dominant frequency (DF), SWC did not improve on the contrary for the CG in which all of these parameters increased (p < 0.05). Answers of questionnaire of dyspeptic symptoms are collected in table 2. Parameters of EGG correlated with dyspeptic symptoms: positively fasting dominant frequency of slow wave (DF) with feeling of food retention in stomach (R = 0.55, p = 0.03) and negatively% of tachygastria with lose of appetite ((R = -0.53, p = 0.04). In fasting period% of arrhythmic positively correlated with vomiting (R = 0.6, p = 0.02).

Conclusion

Gastric and colorectal cancer affects gastric myoelectric activity by decreasing normogastria, slow wave coupling. Gastric myoelectric motility response to food in patients was abolished. Observed gastric electric motility dysfunction may be a result of autonomic system activity disturbances induced by neoplastic processes.

Table 1: P-159

Table 2: P159. Questionnaire of dyspeptic symptoms (n=14)