153P - Factors affecting survival in patients with pulmonary metastases from colorectal cancer with previously resected liver metastases who underwent lung...

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Colon Cancer
Rectal Cancer
Surgery and/or Radiotherapy of Cancer
Presenter Franco Lumachi
Citation Annals of Oncology (2015) 26 (suppl_1): 45-47. 10.1093/annonc/mdv051
Authors F. Lumachi1, F. Mazza2, A. Del Conte3, G.B. Chiara4, S.M.M. Basso4
  • 1Department Of Surgery Oncology & Gastroenterology (discog), University of Padua, School of Medicine, 35128 - Padova/IT
  • 2Pneumology, S. Maria degli Angeli Hospital, 33170 - Pordenone/IT
  • 3Oncology Unit, S. Maria degli Angeli Hospital, 33170 - Pordenone/IT
  • 4Surgery 1, S. Maria degli Angeli Hospital, 33170 - Pordenone/IT

Abstract

Aim/Background

Lung and liver are the most common sites of metastases from colorectal cancer (CRC), and approximately 15% of patients with CRC will develop pulmonary metastases (PMs) requiring surgery. After resection of PMs, the cumulative 5-year overall survival (OS) is similar to that of patients who underwent resection of liver metastases (LMs). However, the presence of simultaneous LMs and PMs is usually considered an adverse prognostic factor. The purpose of this study was to evaluate factors affecting survival after lung metastasectomy in patients with CRC who had previously undergone liver resection for LMs.

Methods

Twenty-two patients (14 men, 8 women, median age 67 years, range 48-77 years), previously treated for CRC, were identified as having PMs, and subsequently scheduled for pulmonary metastasectomy. Twelve (Group 1) patients had already undergone liver resection for LMs, while the others (N = 10) had never developed LMs (Group 2).

Results

The 5-year OS was 16.7% and 30% in Groups 1 and 2, respectively (χ2 = 0.03, p = 0.04; OR = 2.09, 95%CI 1.06-4.11). Overall, 32 PMs (median 1.5, range 1-5 nodules per patient) were removed (G1 = 20, G2 = 13, χ2 =2.97, p = 0.08), and the mean size of the metastases was 17 ± 5 mm (G1 = 16 ± 3 mm; G2 = 19 ± 4 mm; t = 2.01, p = 0.06). In both Groups (G1 vs. G2), no significant correlation was found between age of the patients and size of the PMs (R = –0.560, p = 0.09 vs. R = –0.58, p = 0.08), and between age and OS (R = 0.52, p = 0.08 vs. R = 0.20, p = 0.58). There was a weak but significant inverse correlation between size and OS only in G2 patients (R = –0.64, p = 0.04). Multivariate analysis showed that the number (>1) of PMs represented the only independent risk factors affecting OS (log-rank test = 4.39, p = 0.04).

Conclusions

In patients with CRC the occurrence of PMs after liver resection for LMs is a weak adverse prognostic factor, as well as the age of the patients and size of the PM. However, regardless of the previous hepatic involvement, is the presence of multiple PMs that affects significantly survival.

Disclosure

All authors have declared no conflicts of interest.