P-144 - Clinical Features and Outcome of Advanced Cholangiocarcinoma

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Hepatobiliary Cancers
Pathology/Molecular Biology
Presenter B. Kandel
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors B. Kandel, Y. Singh
  • Tribhuvan University Teaching Hospital, Kathmandu/NP

Abstract

Introduction

Cholangiocarcinoma is a cancer with very poor prognosis. Patients with this cancer often present in advanced stage and the quality of life is further impaired by symptoms like pruritus, jaundice and ascites. In this study we reviewed the clinical features and outcome of patients with advanced cholangiocarcinoma.

Methods

It is a retrospective study of patients diagnosed as cholangiocarcinoma in Tribhuvan University Teaching Hospital Kathmandu Nepal over one year period (January 2014 to December 2014) Patients data were obtained from medical records and information on duration of survival were obtained by phone calls to the patients care taker.

Results

There were total of 52 patients of cholangiocarcinoma admitted in the year 2014 AD. Twenty four (46%) were male and 28(54%) were female. Mean age at diagnosis was 62 ± 11 years. Jaundice (87%) and pain abdomen (60%) were the main symptoms. Sixteen (31%) patients were distal cholangiocarcinoma, 29 (56%) were perihilar and 7(13%) were intrahepatic cholangiocarcinoma. Nine (17%) patients were in earlier stage and amenable to surgical resection of the tumor and 43(83%) were unresectable. Out of 43 unresectable patients 31(72%) underwent palliative biliary drainage internal or external. Twenty two (71%) of patients with biliary drainage need multiple procedures due to dislodgement or blockage of drainage tube. All the patients with unresectable tumor were treated with supportive care without chemotherapy. Median duration of survival of unresectable cholangiocarcinoma was 3.6 months.

Conclusion

Cholangiocarcinoma is usually presents in advanced stage and prognosis of these patients is poor. Early detection of disease and curative resection is the only hope for better survival.