734P - Analysis of correlation between clinical features and hepatic dysfunction after transcatheter arterial chemoembolization in patients with primary l...

Date 29 September 2014
Event ESMO 2014
Session Poster Display session
Topics Anti-Cancer Agents & Biologic Therapy
Hepatobiliary Cancers
Presenter Lin Zhou
Citation Annals of Oncology (2014) 25 (suppl_4): iv210-iv253. 10.1093/annonc/mdu334
Authors L. Zhou, H. Wang, D. Ai
  • Department Of Interventional Radiology, Beijing 302 Hospital, 100039 - Beijing/CN

Abstract

Aim

To analyze the correlation between clinical features and hepatic dysfunction after transcatheter arterial chemoembolization in patients with primary liver cancer.

Methods

251 PLC patients treated by TACE were retrospectively analyzed. χ2 test and Logistic regression model were used to assess the correlation between clinical features and hepatic dysfunction after TACE.

Results

40/251 patients(15.9%) presented with hepatic dysfunction after TACE. Univariate analysis showed that tumor diameter ≥ 10cm, Child-Pugh grade, cholinesterase level and portal vein tumor thrombosis(PVTT) were associated with hepatic dysfunction after TACE in PLC patients. Multivariate analysis showed that Child-Pugh grade B, tumor diameter ≥ 10cm and low cholinesterase level were risk factors associated with hepatic dysfunction after TACE in PLC patients.

Conclusions

TACE should be carefully performed to avoid hepatic dysfunction in PLC patients with tumor diameter ≥ 10cm, Child-Pugh grade B, and low cholinesterase level.

Disclosure

All authors have declared no conflicts of interest.