P-065 - Prognostic value of carbohydrate tumor markers and inflammation-based markers in gastric cancer

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Gastric Cancer
Translational Research
Presenter W. Kong
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors W. Kong, Z. Zou, B. Liu, J. Wei, Y. Yang, Y. Zhang, Q. Wang
  • The Comprehensive Cancer Center Affiliated Drum Tower Hospital to Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing/CN

Abstract

Introduction

Gastric cancer is the fourth most common cancer worldwide. In China, most cases are diagnosed as metastatic or recurrent gastric cancer (MRGC) with the5-year survival rate being less than 5%. It is important to obtain simple, feasible and cost-less markers to evaluate the prognosis of the MRGC patients.

Methods

We investigated the correlation of tumor markers such as CEA, CA125, CA19-9, CA24-2, CA72-4 and inflammation-based factors such as mGPS, NLR and PLR with prognosis in 439 MRGC patients.

Results

CA125 was more frequently positive with peritoneal recurrence, and CEA was more frequently positive in patients with liver metastases. In the univariate analysis of survival, the following variables were associated with shorter overall survival (OS): male, previous pathology such as nerves invasion and vessel invasion, elevated CEA, CA72-4, CA125 andCA19-9, and inflammation-based variables such as Alb, CRP, mGPS, PLR, NLR, Hb, LDH, AchE and AKP. In the multivariate analysis, mGPS, CEA and CA125 were independent prognostic factors for OS. An exploration of the potential prognostic index model including the three independent factors was carried out; MSTs for the low-, moderate- and high-risk groups were 12, 10.5 and 5 months.

Conclusion

Elevated serum CEA, CA125 and mGPS inpatients with MRGC are independent negative predictor of prognosis.