666P - Prognostic significance of metastatic lymph node ratio in patients with gastric cancer, an evaluation in north-east of Iran

Date 29 September 2014
Event ESMO 2014
Session Poster Display session
Topics Gastric Cancer
Presenter Ali Taghizadeh Kermani
Citation Annals of Oncology (2014) 25 (suppl_4): iv210-iv253. 10.1093/annonc/mdu334
Authors A. Taghizadeh Kermani1, S.Z. Yahouyan2, M. Ali Akbarian2, M. Seilanian Tousi3, P. Izadpanahi4
  • 1Oncology, Cancer research center(MUMS), 91856 - Mashhad/IR
  • 2Surgical Oncology, Masshad university of Medical siences, Mashhad/IR
  • 3Oncology, cancer research center(MUMS), Mashhad/IR
  • 4Cancer Research Center, Omid Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad/IR

Abstract

Aim

In this study we evaluated the prognostic impact of metastatic lymph node ratio (MLR) in patients with gastric cancer undergoing curative surgical resection.

Methods

A total of 121 patients with gastric adenocarcinoma undergoing curative R0 surgical resection in our institutions between 2003 and 2010 were included in this study. MLR was classified into 3 groups as follows: MLR0; 0, MLR1; >0-0.33 and MLR2; 0.34-1. We used Kaplan-Meier method to calculate survival rates and log rank test to compare survival curves between groups. Cox proportional hazards model was utilized for multivariate analysis.

Results

The median age of patients was 65 (range; 32 to 89) with a male to female ratio of 91/30 (3.03). 88 patients underwent total gastrectomy (72.5%) and 33 subtotal gastrectomy (27.5%). With a median total retrieved lymph node of 11 (range; 6 to 44), the MLR0 to MLR2 was calculated in 28(23.1%), 31(25.6%) and 62 (51.2%) patients respectively. MLR2 (>0.33) was significantly associated with higher Tumor stage (T1-T2: 18.7% vs. T3: 56.2%, p = 0.002). With a median follow up time of 12 months (range; 2-88), the 3-year survival in patients with MLR0, MLR1 and MLR2 was 75.1%, 54.8% and 9.5% respectively (p value < 0.001). Tumor location (p < 0.01), tumor stage (p < 0.01) and lymph node stage (p < 0.001) were also significant predictor of survival. MLR was also significant correlated with survival in 91 patients with less than 15 obtained lymph nodes (p < 0.001). Cox-regression multivariate analysis showed MLR as being the most important and independent predictor of survival (p < 0.001).

Conclusions

MLR with cut off point of 0.33 can be used as an independent prognostic factor in gastric cancer patients undergoing curative surgical resection. This factor can effectively predict survival even in cases with insufficient (<15) retrieved lymph nodes.

Disclosure

All authors have declared no conflicts of interest.