P-0200 - Ki 67 as a marker of prognosis in Morocco colorectal cancer

Date 28 June 2014
Event World GI 2014
Session Poster Session
Topics Colon Cancer
Rectal Cancer
Translational Research
Presenter Rajae Najib
Citation Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165
Authors R. Najib1, K. Daoudi2, Z. Hijri Fatima3, S. Arifi3, N. Mellas3
  • 1Hassan II University Hospital, Fez/MA
  • 2Medical Oncology Department, HASSAN II University Hospital, Fez/MA
  • 3Department of Medical Oncology, Hassan II University Hospital, Fez/MA

Abstract

Introduction

KI 67 is a protein associated with cell proliferation which is expressed in all phases of the cell cycle except G0. Several studies have shown that KI67 may be an ominous prognostic marker in malignant tumors. Our intention was to identify prognostic significance of Ki67 in patients with colorectal cancer.

Methods

65 patients with colorectal cancer were selected, the KI 67 expression was examined using immunohistochemistry with the monoclonal antibody MIB-1. The patients ranged from 24 to 77 years of age and consisted of 39 women and 26 men.

Results

40 cases (62%) had more than 50% positive tumor cells and 15 cases(38%) less than 50%. The tumors showed a wide range of Ki67 expression from 15 to 90%, which indicated a variation in proliferative activity. There was no significant relationship between Ki67 expression and sex, age, tumor location. As regard the differentiation, Ki67 was high in well an moderately as compared to poorly differentiated adenocarcinomas. Multivarable modeling indicated that Ki67 value more than 50% remained a negative prognostic factor (HR = 1,52; 95% CI, 1.01-2.59). Overall survival was significantly greater for patients with Ki67 less than 50% than more this value (p = 0,002).

Conclusion

Ki67 is independent predictor of survival and thus may be useful in indentifying patients at high risk of colorectal cancer mortality.