P-310 - CLIMB: An EORTC-ESSO Prospective colorectal liver metastasis database with an integrated quality assurance program

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Bioethics, Legal, and Economic Issues
Colon Cancer
Rectal Cancer
Presenter C. Caballero
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors C. Caballero1, S. Evrard2, G. Poston3
  • 1European Organization for Research and Treatment of Cancer, Brussels/BE
  • 2Institut Bergonie, Bordeaux/FR
  • 3University Hospital Aintree, Liverpool/UK



For patients with advanced colorectal liver metastases, several oncological and surgical strategies are evolving to increase the both the probability of achieving R0 surgery and the future liver remnant volume. However, very few prospective studies have been done to understand the impact of these strategies. It is not yet clear whether multiple surgeries or prolonged chemotherapy are truly beneficial for those with complex liver metastasis. The primary aim of CLIMB is to evaluate the complication rates, 30-day and 90-day mortality after liver surgery and to establish baseline quality indicators (based on structure, process and outcome) for liver metastasis surgery in Europe.


This is a prospective observational clinical research study (Outcomes study). Patients with unresectable, borderline resectable or initially inoperable colorectal liver metastasis discussed in a multidisciplinary team (MDT) meeting will be registered and prospectively followed up to identify treatment planned after MDT, surgical complications, disease and survival status. At least 100 patients, across 15 sites in 10 countries, who have undergone surgery, will be included for the first analysis planned at 1 year. The second analysis to determine long-term outcomes will be done after 2 years of follow-up from initial surgery. An integrated QA program has been set up. It will involve quality checks and site visits to ensure prospective inclusion of patients through the MDT and data consistency in documenting post-operative outcomes. This will address the expected heterogeneity and serve to build a continued program of QA beyond this study. This study, conducted by EORTC (1409 GITCG) and ESSO will serve as the basis for a long term pan-European Quality Assurance program for surgery.