P-0174 - Association between colorectal cancer survival outcomes and GWAS-identified colorectal cancer susceptibility polymorphism in Korean population

Date 28 June 2014
Event World GI 2014
Session Poster Session
Topics Colon Cancer
Rectal Cancer
Translational Research
Presenter Woog Kang Byung
Citation Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165
Authors W. Kang Byung1, G. Kim Jong1, S. Chae Yee2, K. Jung Min1, Y. Jang1, O. Kwon1, H. Jeon1
  • 1Kyungpook National University Hospital, Daegu/KR
  • 2Kyungpook National University Medical Center, Daegu/KR

Abstract

Introduction

Genome-wide association studies have identified at least 22-single nucleotide polymorphisms (SNPs) that are associated with colorectal cancer (CRC).

Methods

We examined the relationship between these SNPs and survival of 762 individuals with CRC using Sequenom MassARRAY.

Results

Of the 22 SNPs, two SNPs (rs1321311C >T and rs10411210G >T) were significantly associated with survival outcomes CRC. In recessive model, rs1321311TT and rs10411210 TT genotype exhibited worse prognosis in overall survival (OS)(adjusted HR = 2.20; 95% confidence interval = 1.12-4.33; p = 0.0023, adjusted HR = 2.20; 95% confidence interval =1.01-3.95; p = 0.047, respectively) and disease-free survival (DFS)(adjusted HR = 2.05; 95% confidence interval = 1.11-3.78; p = 0.0022, adjusted HR = 1.93; 95% confidence interval = 1.04-3.57;p = 0.037, respectively). Other SNPs were not associated significantly with OS and DFS.

Conclusion

The two SNPs (rs1321311C >T and rs10411210G >T) might be prognostic factors for patients with CRC.