1151P - Goblet cell carcinoids: Characteristics of a Danish cohort of 83 patients

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Neuroendocrine Cancers
Cancer Aetiology, Epidemiology, Prevention
Presenter Ingrid Holst Olsen
Citation Annals of Oncology (2014) 25 (suppl_4): iv394-iv405. 10.1093/annonc/mdu345
Authors I.H. Olsen1, N. Holt2, S. Langer3, J. Hasselby4, H. Grønbæk5, J. Hillingsø1, M. Mahmoud6, M. Ladekarl7, L. Iversen8, A. Kjær9, B. Federspiel4, U. Knigge1
  • 1Dept. Of Surgical Gastroenterology, European NET Centre of Excellence, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2100 - Copenhagen/DK
  • 2Hepatology & Gastroenterology, , European NET Centre of Excellence, Aarhus University Hospital, 8000 - Aarhus/DK
  • 3Dept. Of Oncology, European NET Centre of Excellence, Rigshospitalet, 2100 - Copenhagen/DK
  • 4Dept. Of Pathology, European NET Centre of Excellence, Rigshospitalet, 2100 - Copenhagen/DK
  • 5Hepatology & Gastroenterology, European NET Centre of Excellence, Aarhus University Hospital, 8000 - Aarhus/DK
  • 6Dept. Of Surgical Gastroenterology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2100 - Copenhagen/DK
  • 7Oncology, European NET Centre of Excellence, Aarhus University Hospital, 8000 - Aarhus/DK
  • 8Surgery, European NET Centre of Excellence, Aarhus University Hospital, 8000 - Aarhus/DK
  • 9Dept. Of Clinical Physiology, Nuclear Medicine & Pet And Cluster For Molecular Imaging, European NET Centre of Excellence, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, 2100 - Copenhagen/DK

Abstract

Aim

Appendiceal goblet cell carcinoids (GCCs) exhibit neuroendocrine and adenocarcinoma features. Demographic, pathological features, prognostic markers, treatment and survival are presented.

Methods

Analysis of demography, pathology, prognostic markers, treatment and survival in 83 GCC patients (female/male: 56/27) diagnosed 1992-2013.

Results

At diagnosis 53 patients (64%) had localized appendiceal disease (female/male: 28/25). Thirty patients had disseminated disease (female/male: 28/2). Median age in both groups was 59 years. Chromogranin A, synaptophysin, p53, MUC1 and MUC2 were positive in >90%. Serotonin was positive in 70%. Median Ki67 index was 32% (6-75%). All patients had surgery. Fifty-eight (70%) had radical resections including all 53 patients with localized appendiceal disease. Median overall survival (OS) was 83 months. The 1-, 5-, and 10-year survival rates were 90%, 57%, and 34%, respectively. For localized disease 1-, 5- and 10-year survival rates were 100%, 83%, and 51%, respectively. For disseminated disease 1- and 5-year survival rates were 73% and 11%, and OS was 18 months. Five- and 10 year-survival rates for female/male were 49%/72% and 22%/53%, respectively (p = 0.04). According to the Tang classification group A, B, and C OS was 118, 67 and 23 months, respectively (p < 0.001). Cox regression analysis found focally positive Chromogranin A and non-radical surgery as negative prognostic factors. Ki67 index was not a prognostic factor.

Conclusions

Localized GCCs occur equally in males and females, while disseminated GCCs were more common in females. Median age of patients with localized disease and disseminated disease was identical, suggesting different types of GCCs. The Tang classification based upon morphology was found to be a significant prognostic factor.

Disclosure

All authors have declared no conflicts of interest.