431 - Blood vessels with different characteristics have distinct impact on survival of glioblastoma multiforme patients

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Central Nervous System Malignancies
Presenter Marju Kase
Authors M. Kase1, A. Minajeva2, K. Niinepuu2, S. Kase3, A. Adamson2, M. Saretok2, M. Vardja4, T. Asser5, J. Jaal6
  • 1North Estonia Medical Centre, Oncology and Haematology Clinic, Tallinn/EE
  • 2Faculty Of Medicine, University of Tartu, Tartu/EE
  • 3Nursing, Health Care College, Tartu/EE
  • 4Dept Of Radiotherapy And Oncological Therapy, Tartu University Hospital, Haematology and Oncology Clinic, Tartu/EE
  • 5Dept Of Neurosurgery, Tartu University Hospital, Tartu/EE
  • 6Dept Of Radiotherapy And Oncological Therapy, Tartu University Hospital, 51003 - Tartu/EE

Abstract

Background

Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor in adults. GBMs are highly angiogenic: next to capillaries and bigger blood vessels, microvascular proliferations (MP) forming glomeruloid structures can be found. The aim of our study was to evaluate the prognostic significance of different blood vessel types in GBM.

Methods

Between Jan 2006 and Dec 2008, 42 patients (30–77 years) received postoperative radiotherapy and chemotherapy. Surgically excised GBM tissues were histologically examined for overall proportion of MP (low, medium, high) and the total number of blood vessels (per microscopic field). Also, immunohistochemical staining intensity of CD133 and ICAM-1 were determined in endothelial cells (arbitrary score 0–3). Finally, blood vessel parameters were correlated with patients overall survival.

Results

The overall proportion of MP was low-medium in 39% and high in 61% of GBM patients. The number of blood vessels per microscopic field was 2.5 ± 1.4 (mean ± SD). A positive association was found between the number of blood vessels and endothelial CD133 staining intensity (p = 0.03). However, between the number of blood vessels and endothelial ICAM-1 staining intensity, a negative correlation was detected (p = 0.04). Median survival time of the study group was 10.0 months (95% CI 9.0–11.0). The proportion of MP did not significantly affect survival (log rank test, p = 0.07). However, the survival time clearly depended on the number of blood vessels in GBM tissue (log rank test, p = 0.03). Median survival times for patients with low ( Conclusion

Different types of blood vessels have distinct prognostic impact on survival of GBM patients. These differences have to be taken into account in designing GBM antiangiogenetic therapies. This work was supported by grant ETF8862 and by Roche scientific grant.

Disclosure

M. Kase: This work was partly supported by Roche scientific grant.

A. Minajeva: This work was partly supported by Roche scientific grant.

K. Niinepuu: This work was partly supported by Roche scientific grant.

S. Kase: This work was partly supported by Roche scientific grant.

A. Adamson: This work was partly supported by Roche scientific grant.

M. Saretok: This work was partly supported by Roche scientific grant.

M. Vardja: This work was partly supported by Roche scientific grant.

T. Asser: This work was partly supported by Roche scientific grant.

J. Jaal: This work was partly supported by Roche scientific grant.