P-082 - Gastric cancer in Moroccan patients aged 45 years or younger: Clinicopathological features and prognosis

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Gastric Cancer
Cancer Aetiology, Epidemiology, Prevention
Presenter F. Ziani
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors F. Ziani1, S.A. Brahmi2, L. Amaadour3, B. Meryem1, K. Rajae1, Z.L. Fatima1, A. Samia1, M. Nawfel4
  • 1Department of Medical Oncology, Fez/MA
  • 2Hassan II University Hospital, Fez/MA
  • 3University Hospital of Hassan II Oujda Morocco, Fez/MA
  • 4Univesity Hospital of Hassan II, Fez/MA

Abstract

Introduction

Gastric cancer is rare in young persons and little has been studied about the prognosis and clinicopathological features of this disease. Also the outcomes of treatment in this situation are the subject of controversy. We conduct a retrospective study about gastric cancer in young Moroccan patients.

Methods

Over the period from January 2010 to December 2014, a series of 230 consecutive patients were admitted to our medical oncology department for the treatment of gastric cancer. Among them, 60 were aged 45 years or younger. The aim of this study is to identify the clinicopathological features and the prognosis of gastric cancer in young Moroccan patients

Results

The mean patient age was 39 years (range, 25–45 years), and 31 patients were male. Forty-four patients (73%) presented with stage III or IV disease, whereas 16 patients presented with stage I or II disease. Poorly differentiated lesions were present in 50 cases (73%). Resection with curative intent was undertaken in 26 patients, and palliative surgery was performed in 10 patients. In curative intent, adjuvant chemotherapy was performed in 5 cases, adjuvant chemoradiotherapy in 4 cases and peri operative chemotherapy in 7 cases. In palliative situation, chemotherapy was administered in 35 patients. In metastatic situation, the median survival was 6 months (range, 3–14 months). In curative situation, 54% were still alive after a median of follow up of 3 years.

Conclusion

The clinicopathologic characteristics of the patients in our study appear to be concordant with an aggressive disease with predominance of advanced stage disease and undifferentiated subtype. Also, according to our study, the prognosis of gastric carcinoma in adult patients appears to be poorer than the older patients.