32P - Epidemiology, treatment patterns and survival outcome in patients of advanced stage inoperable lung cancer: A tertiary cancer care centre analysis

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Non-Small-Cell Lung Cancer, Metastatic
Cancer Aetiology, Epidemiology, Prevention
Presenter Divyesh Kumar
Citation Annals of Oncology (2015) 26 (suppl_1): 6-9. 10.1093/annonc/mdv044
Authors D. Kumar, M.C. Pant, S. Singh
  • Radiotherapy, CSM Medical University (KG's Medical University) Gandhi Memorial & Associated Hospital, 226003 - Lucknow/IN

Abstract

Aim/Background

Lung cancer is an important cause of mortality and morbidity present worldwide, smoking being its primitive etiological factor. Lung cancer is the fifth most common cancer amongst all malignancies in our cancer registry after Head and Neck, Cervix, Breast, Gastrointestinal and CNS malignancies. This study aims at analysing the epidemiology, treatment pattern and survival outcome for advanced stage inoperable lung cancer at our hospital which is a tertiary cancer care centre in north India.

Methods

A retrospective analysis of case records of 106 patients with advanced stage lung cancer registered from year Aug 2008 to June 2011 were taken into consideration. Data regarding epidemiology, histopathology, stage at diagnosis, treatment plans and survival was collected.

Results

103/106 (97%) patients were males, while only 3 /106 (3%) patients were females. 95/106 (90%)of the patients were smokers, 11/106 (10%) were nonsmokers. Squamous cell carcinoma was present in 90% of patients, 8% had adenocarcinoma and only 2% had small cell cancer as histopathology.83/106(79%) had stage III, 23/106 (21%) patients had stage IV disease. Neoadjuvant chemotherapy followed by concurrent chemoradiotherapy was the treatment modality for stage III disease while palliative radiotherapy and or palliative chemotherapy along with basic supportive care was used for stage IV disease. Median OS of stage III patients was 9.46 ± 1.85 months and 2-year survival rate of 14% while stage IV patients had median OS of 6 ± 1.5 months with a 2-year survival rate of 7%.

Conclusions

The study emphasizes on the need for early detection, interventions and preventive measures in patients of lung cancer as most of the patients present in an inoperable stage leading to an increase in the morbidity as well as mortality rates. It also brings forward the need for a strong anti-tobacco legislation.

Disclosure

All authors have declared no conflicts of interest.