P-155 - Digestive tract cancers in young adults: epidemiologic study and therapeutic results of a Tunisian Series

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Cancer in Young Adults
Cancer Aetiology, Epidemiology, Prevention
Gastrointestinal Cancers
Presenter H. Meganem
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors H. Meganem1, Y. Ben Romdhane2, S. Labidi1, M. Afrit1, H. El Benna1, H. Boussen1, A. Hamrouni3
  • 1Medical Department of Abderrahmen Mami Hospital, Ariana/TN
  • 2Abderrahmen Mami Hospital Ariana, Ariana/TN
  • 3Medical Oncology Department of Abderrahmen Mami Hospital, Ariana/TN

Abstract

Introduction

Digestive tract cancers are rare in patients younger than 40 years, and associated with poor prognosis. Our study aims to analyze the epidemiologic, anatomo-clinical features and therapeutic results of digestive cancer in young adults (DCYA) treated in our department.

Methods

Retrospective study of DCYA treated at our medical oncology department from 2011 to 2014. We reported the data and performed a statistical uni and multivariate analysis of survival by the Log-Rank test and Cox Model

Results

We collected 29 cases (17M/ 12F) with a median age of 32 years [26-39] (10 younger than 30), who consulted for abdominal pain in 13cases, Bowel movement disorder in 7 cases, Digestive bleeding in 6 cases and for poor general health condition in 3 cases. Seven patients had family history of cancer (4 colorectal, 1 breast, 1 ovarian, 1 lung cancer). There were 13 colon cancer, 6 rectal cancer, 8 gastric cancer, 1 small intestine cancer and 1 pancreatic carcinoma. All cases were adenocarcinomas (38% mucinous adenocarcinoma). Fourteen patients had metastatic disease at presentation (peritoneum 5, liver 4, lung1, multiple metastases 4). The treatment was curative in 12 cases and palliative in 17 cases (see table below).

In univariate study, anatomic site, N status, Metastasis, primary surgery and treatment with chemotherapy in metastatic setting are statistically significant, while in multivariate study, only N status had a significant impact.

Conclusion

Most of our cases were diagnosed at advanced stages, explaining the poor outcome and the short survival time at 1 and 2 years. In Tunisia, an oncogenetic counseling has just been instituted with few tests available.

Figure: P-155