PD-0015 - Analysis of Sociodemographic Parameters of Esophageal Cancer and its Association with ABO Blood Group
|Date||27 June 2014|
|Event||World GI 2014|
|Session||Poster discussion session III – Endoscopy|
|Topics|| Oesophageal Cancer
Cancer Aetiology, Epidemiology, Prevention
|Citation||Annals of Oncology (2014) 25 (suppl_2): ii5-ii13. 10.1093/annonc/mdu164|
A. Kapoor1, N. Kumar2, S. Lal2, R. Nirban3
Esophageal cancer (EC) is the eight most common cancers worldwide, accounting for 3.2% of total new cases in 2012. Despite various advances in the treatment of OC, being one of the least responsive tumors of cancer therapy, the overall prognosis remains poor. Also, it shows marked differences in incidences within a particular geographical region. Also, some studies have shown its correlation with particular blood groups. In this perspective, a better understanding of the possible etiological factors of the disease may provide opportunities for its primary prevention.
The present study was carried out in a regional cancer center of North West India which has witnessed 55,242 new cancer registrations in the last ten years, of them, 3667 (6.64%) patients had EC. For extracting the data, the computerised data, hard copies of the files, and also, radiotherapy files of the patients suffering from EC were reviewed. The sociodemographic parameters including the addiction pattern and blood grouping were studied. The data for control population was obtained from the regional blood bank. Allele frequency was calculated using the Hardy Weinberg law.
53.4% patients were males with male: female ratio of 1.15: 1 indicating higher incidence of EC in females of North West India. The mean age was 54.6 ± 11.74 years, majority of patients being illiterate and of low socioeconomic status. Squamous cell carcinoma (SCC) was identified in 84.4% of the patients. 42% and 26% of the patients were addicted to smoked and smokeless tobacco, respectively. There was a statistically significant difference in the distribution of ABO blood groups between patients and general population (χ2 = 8.382, P = 0.039). In the patient group, the frequencies of blood groups B and AB were more than and frequencies of blood groups. These findings were also seen in female subgroup (χ2 = 7.088, P = 0.069). However in male subgroup, the distribution of ABO blood groups did not significantly differ between cases and controls (χ2 = 3.948, P = 0.267). SCC of lower part of esophagus showed significant differences as compared to the general population, blood group B was found in higher incidence (χ2 = 8.067, P = 0.044). There was also a statistically significant difference in the status of Rh blood groups between patients and general population (χ2 = 5.582, P = 0.018). Presence of Rh antigen was about 6.5% less prevalent in EC patients (88.5%) in comparison to general population (95%). Female subgroup shows 4.2% less prevalence of Rh antigen in comparison to male subgroup. The gene frequencies of blood group B were 0.361 in cancer patients, which was higher than that of the controls population (0.265), and the relative risk B: O was 1.69 with statistical significance.
Individuals with blood group B are more susceptible to Squamous cell carcinoma of esophagus.