2P - Role of magnetic resonance imaging in non-palpable breast cancer to diagnose breast cancer with stereo-guided biopsy

Date 08 May 2014
Event IMPAKT 2014
Session Welcome reception and Poster Walk
Topics Breast Cancer
Imaging, Diagnosis and Staging
Presenter Hiroyuki Takayanagi
Citation Annals of Oncology (2014) 25 (suppl_1): i1-i1. 10.1093/annonc/mdu061
Authors H. Takayanagi
  • Breast Surgery, Shizuoka general hospital, 4208527 - shizuoka city/JP



The prevalence of non-palpable breast cancer has increased since the introduction of breast screening programs, and stereo-guided biopsy plays an important role in diagnosing non-palpable breast cancer. Although magnetic resonance imaging (MRI) is useful in detecting breast cancer, the relationship between stereo-guided biopsy and MRI has not been systematically assessed. In addition, according to some studies, breast density provides false-negative breast cancer detection rates. Therefore, this study aimed to evaluate the role of MRI in performing stereo-guided biopsy, particularly its relationship with breast density.

Materials and methods:

In this study population, there were 274 non-palpable lesions (254 patients) as detected by mammography. The breast imaging reporting and data system (BI-RADS) classification was used to evaluate the breast density. The patients underwent stereo-guided biopsy in our hospital between January 2011 and September 2013. We assessed the utility of MRI before patients underwent stereo-guided biopsy and examined whether MRI should be performed.


Eighty lesions (29.2%) had breast cancer. The sensitivity and specificity of MRI were 53.3% and 92.4%, respectively. In dense lesions (BI-RADS category 3 and 4), negative predictive value (NPV) of MRI was low (77.2%) compared with thin breast tissue (86.2%; BI-RADS category 1 and 2). MRI revealed 20 malignant lesions, whereas breast ultrasound revealed no sign of malignancy. A total of 34 of 274 lesions (12.4%) for which both MRI and ultrasound were not able to detect malignancy had breast cancer (4 invasive ductal carcinoma, 30 ductal carcinoma in situ).


We conclude that MRI may be beneficial to determine whether patients should undertake stereo-guided biopsy. NPV of MRI is comparatively low in dense breast tissues; therefore, these patients should undergo stereo-guided biopsy regardless of the negative MRI finding role of magnetic resonance imaging in non-palpable breast cancer to diagnose breast cancer with stereo-guided biopsy


All authors have declared no conflicts of interest.