314 - Moving from 2D to 3D-CRT planning of chest wall for postmastectomy breast cancer patients: Mansoura University experience

Date 28 September 2012
Event ESMO Congress 2012
Session Publication Only
Topics Breast Cancer
Surgery and/or Radiotherapy of Cancer
Presenter Ibrahim Awad
Authors I. Awad, D. Zayed, N. Abotouk, T. Dawood
  • Clinical Oncology, Mansoura University Hospital School of Medicine, 35511 - Mansoura/EG

Abstract

Background

This study evaluates the dose distribution of the wedged tangential beam three-dimensionally planned conformal radiotherapy (3D-CRT) compared to the previously used (5 years ago) two-dimensionally(2D) planned radiotherapy of the chest wall for postmastectomy breast cancer patients in Clinical Oncology and Nuclear Medicine Department - Mansoura University.

Patients and methods

Thirty six breast cancer patients were randomized for planning by both the standard 3D-CRT and 2D-RT techniques for radiotherapy of the chest wall. Dose-volume histograms were carried out by the 3D treatment planning system. They were assessed for the PTV and organs at risk. The total dose was 50 Gy in 25 fractions.

Results

The three–dimensionally planned conformal radiotherapy showed a significantly better homogeneity index of the PTV (chest wall). The ipsilateral mean lung dose was significantly reduced with the tangential beam 3D-CRT plans with an average of 24.6% (1217 cGy versus 1614 cGy). For the left sided breast cancer patients, the mean heart dose was also reduced by an average of 48.6% (718 cGy versus 1398 cGy).

Conclusions

The tangential beam 3D-CRT planning demonstrated a significantly better homogeneity index for the PTV of the postmastectomy breast cancer patients with a statistically significant reduction in the mean doses of the ipsilateral lung and the heart for the left –sided breast cancer patients.

Disclosure

All authors have declared no conflicts of interest.