327P - Survival analysis of breast cancer patients treated at a tertiary care centre in Southern India

Date 29 September 2014
Event ESMO 2014
Session Poster Display session
Topics Breast Cancer, Early Stage
Presenter Rajkumar Arumugham
Citation Annals of Oncology (2014) 25 (suppl_4): iv85-iv109. 10.1093/annonc/mdu327
Authors R. Arumugham, A. Raj, M. Nagarajan, R. Vijilakshmi
  • Medical Oncology, G.Kuppusamy Naidu Memorial Hospital, 641037 - Coimbatore/IN

Abstract

Aim

To analyse the 5 yr survival of breast cancer patients treated at a tertiary care centre in Southern India and the impact of various prognostic factors includind age, luminal subtypes and stage on survival.

Methods

This is a retrospective study of 324 patients with breast cancer treated at a tertiary care centre in southern Indian in the years 2008-09 with a followup of 5 yrs. Case records of these patients were analysed for baseline characteristics including receptor status and other prognostic factors, treatment given and survival. Overall survival curves were estimated using the Kaplan Meier method. A multivariate analysis and log rank test was done to analyse the interaction of various prognositc factors and survival.

Results

A total of 324 patients were included in the analysis. Among these patients 60% had early breast cancer(stageI & II), 24% locally advanced and 4% metastatic disease at presentation. A relatively high incidence of triple negative cancers were seen(24%) while Her2 positive disease was seen only in 8%. The 5 yr overall survival for stage I patients was 95%, stage II was 92%, stage III was 70% and stage IV 21%. Her2 positive patients with early breast cancer fared significantly worser when compared to luminal types (74% for Her2 type, 77% for TNBC, 90% for Luminal A and 99% for luminal B cancers.

Conclusions

Survival data on breast cancer patients in developing countries like India is largely lacking in the literature. Previously reported data from a few tertiary care centres mostly in northern and western parts of India revealed a relatively poorer prognosis stage wise compared to western literature. India is a vast country with differing cultures, food habits and a varied population. The inherent biology of the disease, stage at presentation and response to treatment is likely to differ within different parts of the country.This study is one of the few that provide data on the survival patterns of breast cancer patients in Southern India. Our study revealed that a substantial number of patients present with early disease and they have a good survival on par with western literature. The shift to earlier stages of presentation with consequent better survival could be due to increasing awareness of the disease, higher literacy rates in this part of the country, availability of specialised treatment centres and better socio-economic conditions.

Disclosure

All authors have declared no conflicts of interest.