287P - Study of stromal CD10 overexpression in invasive breast cancer and its relationship with clincophathologic factors

Date 01 October 2012
Event ESMO Congress 2012
Session Poster presentation III
Topics Breast Cancer, Early Stage
Translational Research
Presenter Ali Taghizadeh Kermani
Authors A. Taghizadeh Kermani1, A. Jafarian2, R. Ashabe Yamin2, M. Seilanian Toosi1, L. Pourali3, A. Omidi Ashrafi2
  • 1Oncology, MUMS, Mashhad/IR
  • 2Pathology, MUMS, Mashhad/IR
  • 3Gynecology, MUMS, Mashhad/IR

Abstract

Background

Carcinoma of the breast is the most common non-skin malignancy in women. Invasion and metastasis are considered as the major causes of cancer-related morbidity and mortality. It has long been proposed that secreted proteinases, including the matrix metalloproteinases, play an important role in tumor progression and mediating extracellular matrix remodeling. More recently, it has been suggested that extracellular proteinases also regulate growth factors and cytokines that may contribute to tumor progression. CD10 is a 90-110kd cell surface zinc-dependent metalloprotease. Since CD10 is structurally similar to matrix metalloproteinase and stromelysin it may facilitates cancer cell invasion and/or metastasis. The aim of this study was to investigat the rate of CD10 expression in the stromal cells of invasive ductal carcinomas of breast immunohistochemically and clarify its corelation with other clinicopathological factors of the disease.

Methods

100 patients with histopathologic diagnosis of IDC and 50 patients with fibroadenoma of breast (as the control group) were selected and 150 parafin blocks were obtained. The stained slides by IHC method for CD10 marker were examined separately by two pathologists and discrepancies were reviewed in a common session to get the final result.

Results

Stromal CD10 was detected in 28% of the IDC. No immunoreactivity was identified in the stromal cells of normal breast. Stromal CD10 expression in IDC was significantly correlated with tumor size (P < 0.001), histologic grade (P < 0.001), the presence of nodal metastases (P < 0.001) and estrogen receptor negative status (P = 0.003).

Conclusion

Stromal CD10 expression in IDC is closely correlated with invasion and metastasis and it may play an important role in the pathogenesis of IDC.

Disclosure

All authors have declared no conflicts of interest.