68P - Prognostic value of periostin (PN) expression in early breast cancer (BCa): Long-term mortality outcomes

Date 07 May 2015
Event IMPAKT 2015
Session Welcome reception and Poster Walk
Topics Breast Cancer, Early Stage
Translational Research
Presenter Pier Vitale Nuzzo
Citation Annals of Oncology (2015) 26 (suppl_3): 15-24. 10.1093/annonc/mdv117
Authors P.V. Nuzzo1, A. Rubagotti1, L. Zinoli2, S. Salvi3, S. Boccardo3, F. Boccardo1
  • 1Department Of Internal Medicine, School Of Medicine, University Of Genoa, IRCCS AOU San Martino - IST-Istituto Nazionale per la Ricerca sul Cancro, 16132 - Genova/IT
  • 2Academic Unit Of Medical Oncology, IRCCS AOU San Martino - IST-Istituto Nazionale per la Ricerca sul Cancro, 16132 - Genova/IT
  • 3Histopathology And Cytology Unit, IRCCS AOU San Martino - IST-Istituto Nazionale per la Ricerca sul Cancro, 16132 - Genova/IT

Abstract

Body

Background: Periostin (PN) is a secreted cell adhesion protein critical for carcinogenesis. In BCa it is overexpressed compared to normal breast, and a few reports suggest its potential role as prognostic marker.

Aim: Present study was conceived to evaluate the prognostic value of PN expression in respect to the correlation with clinical pathological features and all-cause and BCa-specific mortality.

Methods: A series of 200 BCa samples was investigated by immonoistochemistry with a polyclonal anti-PN antibody using Tissue Macroarrays (TMAs). Epithelial PN expression were scored according to the percentage of colored cells, and the median values were used as arbitrary cut-off. The relationship between epithelial PN expression and clinical-pathological features, tumor phenotype and the risk of mortality following surgery were analyzed. Appropriate statistics, including the Fine and Gray competing risk proportional hazard regression model, were used.

Results: Of the 200 BCa specimens 80 (40%) were positive for PN expression. Kaplan-Meier analysis indicated that epithelial PN expression (negative vs positive) was not associated with all-cause or BCa-specific mortality (p = 0.6 and p = 0.5, respectively), after a median follow-up time of 225 months. However when analysis was limited to the 80 women with epithelial PN positive tumors, PN expression was a strong prognostic predictor, as a statistically significant survival advantage favored the low positive women, especially with regard of BCa-specific mortality (p = 0.03). These trends were confirmed by multivariate analysis (p = 0.015). Competing risk analysis, showed that PN epithelial expression was strongly correlated with BCa specific mortality (p = 0.03) while it was not at all with BCa-unrelated deaths (p = 0.8).

Conclusions: Although requiring further validation through larger studies, our findings suggest that epithelial PN plays a crucial role in BCa carcinogenesis. The presence of epithelial PN expression could represent a predictor of worse survival outcomes, being able to discriminate a subgroup of women with a very low BCa mortality risk even at a so long follow up time.

Disclosure: All authors have declared no conflicts of interest.