1084P - Establishing clinical research in a limited resource setting, "acute lymphoblastic leukemia model"

Date 27 September 2014
Event ESMO 2014
Session Poster Display session
Topics Leukaemia
Bioethics, Legal, and Economic Issues
Presenter Wafaa Rashed
Citation Annals of Oncology (2014) 25 (suppl_4): iv373-iv373. 10.1093/annonc/mdu343
Authors W.M. Rashed1, S. Ezzat2
  • 1Research, Children's Cancer Hospital Egypt, 11441 - Cairo/EG
  • 2Research Department, Children's Cancer Hospital 57357 - Egypt, 11441 - Cairo/EG

Abstract

Aim

One of the most important challenges that face Children's Cancer Hospital-57357 since its start, is establishing research on Childhood Acute Lymphoblastic Leukemia (ALL) in a limited resource country like Egypt.

Methods

Research Department was established in November-2008. it was the first time in Egypt to introduce the concept of forming team for each disease. A multidisplenary team of ALL was formed. The Team is composed of pediatric oncologist, Radiologist, clinical pathologists, flow cytometry specialist, cytogenetics specialist, basic researcher, radiologist, radiotherapist, psychologists, pharmacist, epidemiologist and clinical researchers. In parallel, and with the help of clinical researchers, a database of ALL patients was established. Training curriculum for clinical researchers included 1- Scientific writing workshop, 2- "The principles and practice of clinical research" course from Harvard medical school, 3- Cancer Registry training.

Results

The above mentioned steps had a marvelous impact on childhood ALL. Initially, a genetic epidemiology grant in ALL funded by US-NIH was obtained. Based on the results of this grant we applied to another grant on " Genome wide Association Study in ALL" to get fund and complete our research to identify the cause of ALL in Egyptian population and was obtained.The presence of ALL database and statistical analysis of the survival, allow them to 1- hold collaboration with St Jude Research Hospital in special risk protocol that allow both check quality of flow cytometry results, cytogentics results so enhance the quality and allow rapid consultation on complicated cases, 2- the presence of hospital based-cancer registry for ALL,3- Supplying biobank with samples that help in future research, 4- rapid statistics of the number of relapsed and died patients. In addition to Production of patient education booklet. The challenges become clear and the future plan to make strategy become mandatory: 1- Identifying the cause of relapse, 2- Route-cause analysis for patient died during induction and in complete remission, 3- The plan to make translational research and individualized treatment. 4- Using isimple audio-visual materials for education.

Conclusions

The presence of clinical research has an impact on the childhood ALL patients, staff and the institution.

Disclosure

All authors have declared no conflicts of interest.