131P - Intrapleural treatment with hedgehog antagonist in a rat bioluminescent model of mesothelioma recurrence
|Date||28 March 2014|
|Session||Lunch and poster display session|
|Topics|| Basic Science
|Citation||Journal of Thoracic Oncology (2014) 9 (Supplement 9): S7-S52. 10.1097/JTO.0000000000000131|
M. Meerang1, O. Lauk1, E. Felley-Bosco2, S. Arni1, B. Bitanihirwe1, R.A. Stahel2, W. Weder1, I. Opitz1
Tumor recurrence remains a challenge after complete resection of malignant pleural mesothelioma (MPM). Stem cell activation by the hedgehog pathway was detected in MPM, thus we hypothesized that the local application of a hedgehog antagonist could suppress the growth of MPM after resection. Here, we aim to use an immuno-competent rat bioluminescent MPM model to test the efficacy of local intracavitary treatment with the FDA approved hedgehog antagonist in the prevention of MPM recurrence.