92P - Social deprivation and radical treatment of stage III NSCLC

Date 17 April 2015
Event ELCC 2015
Session Poster lunch
Topics Anti-Cancer Agents & Biologic Therapy
Non-Small-Cell Lung Cancer, Locally Advanced
Psychosocial Aspects of Cancer
Surgery and/or Radiotherapy of Cancer
Presenter Mick Button
Citation Annals of Oncology (2015) 26 (suppl_1): 24-28. 10.1093/annonc/mdv049
Authors M. Button1, R. Evans1, C. Bullock2, E.M. Rees2
  • 1Clinical Oncology, Velindre Cancer Centre Velindre Hospital, CF14 2TL - Cardiff/UK
  • 2Student, Velindre Cancer Centre Velindre Hospital, CF14 2TL - Cardiff/UK

Abstract

Aim/Background

Welsh Government publishes data on the relative social deprivation of patient's residence. The Welsh Index of Multiple Deprivation (WIMD) is a weighted index of 8 domains of deprivation (including income, employment, health and education), giving one summary value which can be used to compare relative social deprivation in different geographical locations. We hypothesised that outcomes after treatment of NSCLC may vary by the social deprivation of patients' area of residence.

Methods

Single institution retrospective review of 9 years' treatment (2005-2013) of stage III NSCLC, analysing survival against the Welsh Index of Multiple Deprivation. Patients were divided in 4 quartiles based on the WIMD, generated from the post-code of their home.

Results

157 patients were indentified with stage III NSCLC who were treated with radical intent. There was no difference in age at presentation between WIMD cohorts. A non-significantly greater proportion of patients from more deprived areas were of performance status 2, likewise there was a non-significantly greater use of chemo-radiotherapy (compared to radiotherapy alone) in patients from less deprived areas There was no significant difference in OS when cohorts of patients from more or less deprived areas were compared (p = 0.42), however long term survival did appear to be greater in those patients from less deprived areas (5 year survival (35% vs 5%) although numbers were very small. Interestingly, median planning target volume was greater in patients from less deprived areas, suggesting that patients from more deprived areas are not presenting with larger volume disease.

Conclusions

For stage III NSCLC, the relative social deprivation index of where a patient lives does not impact significantly on treatment received or on survival after radical radiotherapy, despite a greater proportion of patients from more deprived areas being of PS 2 and slightly greater use of chemo-radiotherapy in patients from less deprived areas. We believe that analysing patterns of presentation and outcome by social deprivation index within the entire population of patients with NSCLC warrants further work.

Disclosure

All authors have declared no conflicts of interest.