1544P - Risk of venous thromboembolism in patients receiving cisplatin based chemotherapy: A retrospective cohort study

Date 28 September 2014
Event ESMO 2014
Session Poster Display session
Topics Anti-Cancer Agents & Biologic Therapy
Supportive Care
Presenter Muhammad Zahir
Citation Annals of Oncology (2014) 25 (suppl_4): iv517-iv541. 10.1093/annonc/mdu356
Authors M.N. Zahir, Q. Shaikh, M. Shabbir-Moosajee, A.A. Jabbar
  • Oncology, Aga Khan University Hospital, 74800 - Karachi/PK

Abstract

Aim

Cancer related thrombosis not only increases morbidity and mortality but also poses a significant financial burden on health care system. Risk of venous thromboembolism (VTE) in these patients substantially increases with the addition of chemotherapy. Lately cisplatin has been implicated as an independent factor. There is little data estimating the risk of venous thromboembolism in patients receiving cisplatin based chemotherapy when compared to other chemotherapeutic agents.

Methods

Patients who had received chemotherapy between October 2010 and October 2012 were retrospectively identified from a single institute cancer registry. 200 patients who had received cisplatin based chemotherapy were identified as the exposed group while 200 patients who had received non-cisplatin based regimens were identified as the non-exposed group. Patients were evaluated for development of VTE throughout the entire duration of therapy and one month thereafter. Cox proportional hazard model was used to compute relative risks with 95% confidence intervals.

Results

The baseline characteristics were similar in the two groups. Mean age for the entire cohort was 55.4 ± 10.7 years and male to female ratio was almost 1:1. On univariate analysis, cisplatin based chemotherapy, presence of central venous catheter, female gender, poor performance status, high risk stratification according to the Khorana model and use of granulocyte colony stimulating factor were all significantly associated with the development of VTE. The crude risk ratio of the incidence of VTE in cisplatin group was 2.8 (95% CI, 1.4–5.6) times compared to the non-cisplatin group. When the risk ratio was adjusted for the above variables in multivariable analysis, it increased to 3.3 (95% CI, 1.6–6.9) compared to control.

Conclusions

A high incidence of VTE in patients receiving cisplatin based chemotherapy was demonstrated in this study. Prospective studies are warranted to establish this observation with certainty and to explore the possible use of thromboprophylaxis in patients receiving cisplatin based chemotherapeutic regimens.

Disclosure

All authors have declared no conflicts of interest.