P-264 - First cycle dose calculation in obese patients with colorectal cancers

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Anti-Cancer Agents & Biologic Therapy
Colon Cancer
Rectal Cancer
Cancer in Special Situations
Presenter E. Una Cidon
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors E. Una Cidon1, P. Alonso2, S. Needham3, T. Hickish3
  • 1NHS Foundation Trust, Bournemouth/UK
  • 2Clinical University Hospital, Valladolid/ES
  • 3Royal Bournemouth Hospital NHS Foundation Trust, Bournemouth/UK

Abstract

Introduction

Optimal doses of chemotherapy drugs are established through randomized clinical trials. In adult patients, chemotherapy drug dosing is based on the patient's estimated body surface area (BSA) and there is evidence that reductions from standard dose may compromise survival in the curative setting. However, many oncologists prefer to cap the BSA at 2.0m2 rather than use the estimated BSA.

We have carried out an audit in our institution to know further about our practices in patients with colorectal cancers in the adjuvant or neoadjuvant settings.

Methods

We evaluated those patients with colon or rectal tumours who underwent adjuvant or neoadjuvant chemotherapy. All these patients had a BSA higher than 2. We assessed how we calculated the dose for the first cycle, reasons for dose reductions if any, toxicities grade 2 or above with the first cycle and dose for the second cycle if previously reduced.

Results

We evaluated 35 patients, 24 colon, 11 rectum. 23 male, 12 female. Median BSA 2.2 (2.1-2.4). Median age 59 (43-74). In 5 patients dose of chemo was reduced by 20% for the first cycle based on comorbidities and/or PS. In 3 of them, the dose was full for the second cycle. In 12 patients dose was capped at 2.2 and 8 of them developed toxicities above grade 2 with the first cycle. All the rest received the dose adapted to the BSA.

Conclusion

Although the guidelines recommend prescribing chemotherapy according to BSA, there are still some limitations supporting this thought and previous clinical experience seems to play still an important role in dose calculations.