hand-foot skin reaction

A dose-dependent skin reaction characterised by sharply demarcated, erythematous, oedematous, painful and very tender blisters that evolve into inflamed and painful skin adjacent to the calluses. The lesions typically localize to areas of pressure or friction on the skin, such as on the heels, metatarsal heads, and areas of friction caused by shoes or manual labour.

Last update: 26 August 2014