US Incidence and Mortality

Chapter 1 - Epidemiology, Pathogenesis, and Risk Factors

US-incidence-mortality-1

Source: Siegel R, et al. Ca Cancer J Clin 2014;64:9-29

Lung cancer is the leading cause of cancer-related death in both genders worldwide, expected to account for 224 210 new cases and 159 260 deaths in the USA, for the year 2014.

It is the second most common solid tumour type in both genders, after prostate cancer in men and breast cancer in women.

Lung cancer is the cause of 28% and 26% of all male and female cancer-related deaths, respectively, exceeding prostate and breast cancer mortality.

US-incidence-mortality-2

Source: Siegel R, et al. Ca Cancer J Clin 2014;64:9-29

Lung cancer US incidence rates in both genders have been increasing from the 1970s, until the mid 1980s in men and the late 1990s in women.

Incidence is now beginning to decline, possibly as a consequence of a reduced smoking prevalence. Differences in lung cancer incidence patterns between men and women reflect mainly historical disparities in smoking habits.

Cigarette smoking prevalence peaked about 20 years later in women than in men.

US-incidence-mortality-3

Source: Siegel R, et al. Ca Cancer J Clin 2014;64:9-29

US lung cancer death rates rose for most of the 20th century, peaking at the beginning of the 1990s for men and almost two decades later for women.

Lung cancer death rates have followed the same trend as smoking prevalence and incidence rates, demonstrating the strong correlation between the major risk factor and the disease and the poor prognosis of this malignancy, respectively.

Recently, a steady decline in lung cancer death rates has been described in both sexes, as a result of combined improvements in primary prevention, control of associated risk factors, and treatment.

Revision Questions

  • What is the trend of lung cancer incidence in the USA in the last 15 years?
  • Is there a difference in lung cancer mortality rates between men and women?
  • What is the percentage of deaths due to lung cancer among all cancer-related deaths?

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Last update: 16 September 2014
Chapter 1 - Epidemiology, Pathogenesis, and Risk Factors
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