DNA damage and repair mechanisms: Current and future

Speaker: Ruth Plummer and Eli Pikarsky

Ruth Plummer and Eli Pikarsky, Co-Chairs of the ESMO Symposium on Signalling Pathways in Cancer 2017, held in partnership with EACR, discuss the important messages resulting from the symposium in terms of the functional aspects of DNA damage and repair mechanisms, the challenges in translating preclinical data into the clinic, opportunities from different approaches to blocking DNA repair and the challenges in overcoming resistance to DNA damaging therapies.

Discussion Points

  1. Lessons learned from research intended to understand DNA damage and repair mechanisms
  2. Challenges in translating science into clinic
  3. Opportunities in term of clinical therapeutic strategies and recent achievements