P-301 - The impact of perioperative hemotransfusions on short-term outcomes after surgical treatment of colon cancer

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics Supportive Care
Colon Cancer
Surgery and/or Radiotherapy of Cancer
Presenter A. Lukashenko
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors A. Lukashenko1, O. Kolesnik1, D. Makhmudov1, A. Burlaka2, M. Volk3
  • 1National Cancer Institute, Kiev/UA
  • 2Bogomolets National Medical University, Kiev/UA
  • 3National Cancer Institute, Kyiv/UA

Abstract

Introduction

Perioperative hemotransfusions (PHT) and concurrent anaemia in colon cancer (CC) patients are still a matter of debate regarding short-term treatment results. The aim of this study is to access the impact of anaemia and PHT on short-term outcomes after surgery for CC

Methods

Patients with CC, with mild and severe anaemia undergoing curative surgery were included. Study group (SG) were treated within an enhanced recovery program, determining no PHT. Control group (CG) were administered with red blood cells (RBCs) transfusion. Degree of anaemia, hemotransfusion status and their impact on postoperative outcomes were assessed.

Results

A total of 280 patients were included; 159 – with mild or severe anaemia, of them 73 SG patients had no PHT and 86 CG patients required RBCs transfusions. No significant difference between age, gender, body mass index, tumor site, stage and extent of surgery were observed. In SG 49 (67%) of patients had mild and 24 (33%) – severe anaemia. In CG – 52 (61%) and 34 (39%) (p = 0.236 and 0.172). Fifty (59%) CG patients received RBCs transfusion (р < 0,01). Postoperative morbidity was higher in CG – 17 (21%) and 8 (10%) (р < 0,05). Postoperative mortality was higher in CG – 4,7% and 0 (р < 0,05). Overall risk (OR) of postoperative complications in patients with severe anaemia was insignificant in both groups – OR = 0,43 (95% CI = 1,125 – 2,9) with р = 0,812 for SG and OR = 0,96 (95% CI = 1.66 – 2,86) with р = 0,113 for CG. PHT was a significant factor of poor postoperative outcome. Among transfused patients 37 (43%) developed complications (р < 0,05). OR and 95% CI were 1,42 (1,03 – 2,01)

Conclusion

Concurrent anaemia in CC patients presented as an invalid risk factor for developing poor short-term results after surgery. PHT significantly increase rates of postoperative morbidity and mortality, influencing the OR