P-132 - The expression characteristics and clinical significance of Ki-67 in gastrointestinal stromal tumors

Date 04 July 2015
Event WorldGI 2015
Session Posters
Topics GIST
Pathology/Molecular Biology
Presenter S. Tang
Citation Annals of Oncology (2015) 26 (suppl_4): 1-100. 10.1093/annonc/mdv233
Authors S. Tang1, B. Zhang2, Y. Yin1, C. Shen3
  • 1West China Hospital, Chengdu City/CN
  • 2Sichuan University, Chengdu/CN
  • 3West China Hospital, Chengdu/CN

Abstract

Introduction

To investigate the expression characteristics and clinical significance of Ki-67 in gastrointestinal stromal tumors.

Methods

Clinical features,immunohistochemiscal characteristics, treatment and follow-up data were retrospectively analyzed. A total of 97 patients with GIST in our institution between July 2012 and September 2013 were identified.

Results

112 patients were enrolled in this study initially,15 patients being lost to follow-up.Complete follow-up and clinicopathology information of 97 patients could be acquired.30 (30.9%) out of 97 cases experienced tumor recurrence or distant metastasis,and 4 (4.1%) patients died. There were no statistically significant difference with respect to age and sex concerning Ki-67 expression (P > 0.05). The difference in tumor size, location,risk stratification, mitotic count was significant (P<0.05),and positive relation was observed between them and Ki-67 (rs>0). The expression of Ki-67 was more stronglyrelated to recurrence or metastasis of GIST compared to mitotic count with the values ofrs0.395,0.266 separately. Cox multivariate analysis indicated that both Ki-67 and mitotic count were independent factors for recurrence-free survival. Ki-67 influenced

the prognosis of medium-high risk patients in survival analysis.

Conclusion

Ki-67 was closely related to tumor size, risk stratification and mitotic count, and could

help to evaluate the prognosis of patients with GIST.