Maintenance BEZ235 treatment following BEZ235 and radiation treatment prolongs the therapeutic effect in colorectal cancer

Date 29 June 2016
Event ESMO World Congress on Gastrointestinal Cancer 2016
Session ESMO World Congress on Gastrointestinal Cancer 2016 - Abstracts book
Presenter F. Wei Ming
Citation Annals of Oncology (2016) 27 (2): 1-85. 10.1093/annonc/mdw199
Authors F. Wei Ming1, H. Chen Yu1, C..W. Wang1, S. Tzeng Yi1, H. Lan Keng1, A.-. Cheng2, S.-. Kuo1
  • 1Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan, /
  • 2National Taiwan University Hospital, Taipei City, Taiwan, /

Abstract

We previously reported that the administration of BEZ235, a dual PI3K/mTOR inhibitor, before radiotherapy (RT) enhances the radiotherapeutic effect in colorectal cancer cells both in vitro and in vivo. For this study, we evaluated whether maintenance BEZ235 treatment following BEZ235 and RT treatment prolongs the antitumor effect in colorectal cancer.