P-0097 - The Initial Institutional Experience about Therapeutic Effect of Un-cooled Single-antenna Microwave Ablation for Large Liver Cancers
|Date||28 June 2014|
|Event||World GI 2014|
|Topics|| Hepatobiliary Cancers
Surgery and/or Radiotherapy of Cancer
|Citation||Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165|
Microwave ablation (MWA) is a treatment modality with long history in the field of local tumor ablation used to treat patients with unresectable liver cancers. A novel microwave generator, designed to deliver automatic-adjusted energy into tissue quickly has been applied at our institution and the aim of this study is to evaluate the safety, efficacy and performance of this new modality used for patients with larger liver tumors.
Twenty-two patients with liver cancers larger than 4 cm in diameter from July 2012 to December 2012 received surgical or percutaneous MWA with more than 12 months of follow-up. MWA was performed using a 915-MHz generator (Avecure Microwave Generator; MedWaves, San Diego, CA) at 28 W and only single 14 G antennas without water-cooled system were used. The patients were followed up with contrast-enhanced computed tomography or magnetic resonance imaging to monitor for tumor recurrence at 1 month and then every 3 months after tumor ablation.
The follow-up duration for the 14 male and 8 female patients (mean tumor size 5.25 cm, range 4.2-8.5; mean age 65.9 years) was 14.6 months in mean. The tumor characteristics are 12 hepatocellular carcinoma and 10 metastatic liver cancers. The complete ablation rate, defined by totally loss contrast-enhancement one month later, was 86.3% (19 of 22). Local recurrence rate was 15.8% (4 of 19). The morbidity and mortality rate was 9.1% and 0%, respectively.
Microwave tissue ablation using this novel system with a single antenna has a high complete ablation rate and acceptable lower morbidity. It was proved to be a fast, easy and effective option for ablation of larger tumor.