P-0217 - Prognostic factors in colorectal cancer: serum LDH levels predict survival in metastatic disease
|Date||28 June 2014|
|Event||World GI 2014|
|Topics|| Colon Cancer
|Citation||Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165|
R. Najib1, K. Daoudi2, Z. Hijri Fatima3, S. Arifi3, N. Mellas3
Lactate dehydrogenase (LDH) is a product regulates the anaerobic transformation of pyruvate to lactate for energy acquisition. The significance of serum elevation in LDH as a predictive indicator for the malignant potential and prognosis in colorectal cancer has not been elucidated. Our intention was to identify prognostic significance of LDH in patients with colorectal cancer.
Our retrospective study involved 195 patients with colorectal cancer; the mean age was 36 years (range: 24-80). There were 109 women and 86 men. The serum LDH level was measured by kinetic immunoassay using selectra III analyser.
The elevation of the serum LDH level was recognized in 136 (70%) patients. In our study the incidence of metastases in patients with elevated serum LDH level were significantly more frequent than in those with a negative serum LDH level, it was 81,8% for patients classified as stage IV. In our study we noted a significant difference of the means of LDH between metastatic patients (stade IV) and non metastatic (p = 0,005) during follow-up we noted a significant decrease of LDH values in patients with favorable outcome.
The present study shows that the elevation of LDH level was thus found to be an indicator of the malignant potential of the tumor as well as a predictor of the prognosis of patients with colorectal cancer.