P-0217 - Prognostic factors in colorectal cancer: serum LDH levels predict survival in metastatic disease

Date 28 June 2014
Event World GI 2014
Session Poster Session
Topics Colon Cancer
Rectal Cancer
Presenter Rajae Najib
Citation Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165
Authors R. Najib1, K. Daoudi2, Z. Hijri Fatima3, S. Arifi3, N. Mellas3
  • 1Hassan II University Hospital, Fez/MA
  • 2Medical Oncology Department, HASSAN II University Hospital, Fez/MA
  • 3Department of Medical Oncology, Hassan II University Hospital, Fez/MA

Abstract

Introduction

Lactate dehydrogenase (LDH) is a product regulates the anaerobic transformation of pyruvate to lactate for energy acquisition. The significance of serum elevation in LDH as a predictive indicator for the malignant potential and prognosis in colorectal cancer has not been elucidated. Our intention was to identify prognostic significance of LDH in patients with colorectal cancer.

Methods

Our retrospective study involved 195 patients with colorectal cancer; the mean age was 36 years (range: 24-80). There were 109 women and 86 men. The serum LDH level was measured by kinetic immunoassay using selectra III analyser.

Results

The elevation of the serum LDH level was recognized in 136 (70%) patients. In our study the incidence of metastases in patients with elevated serum LDH level were significantly more frequent than in those with a negative serum LDH level, it was 81,8% for patients classified as stage IV. In our study we noted a significant difference of the means of LDH between metastatic patients (stade IV) and non metastatic (p = 0,005) during follow-up we noted a significant decrease of LDH values in patients with favorable outcome.

Conclusion

The present study shows that the elevation of LDH level was thus found to be an indicator of the malignant potential of the tumor as well as a predictor of the prognosis of patients with colorectal cancer.