P-0052 - Gastric Cancer in Young Adults: Experience from Nepal

Date 28 June 2014
Event World GI 2014
Session Poster Session
Topics Cancer in Young Adults
Gastric Cancer
Presenter Bishnu Kandel
Citation Annals of Oncology (2014) 25 (suppl_2): ii14-ii104. 10.1093/annonc/mdu165
Authors B. Kandel, P. Kansakar, Y. Singh
  • Tribhuvan University Teaching Hospital, Kathmandu/NP

Abstract

Introduction

Gastric cancer is fourth most common malignancy in the world. In Nepal it is the most common gastrointestinal cancer and a leading cause of cancer related death. Gastric cancer usually affects older individual but it is not rare in younger age group. In this study we compared the clinicopathological profile of young patients with gastric cancer with that of older patients.

Methods

It is a retrospective study of gastric cancer patients admitted in our hospital from January 2012 to December 2013. Data of patients were obtained from the medical record. Information including patients' age, sex, tumor classification, stage of disease, type of surgery was retrieved. Clinical and pathological characters of younger patients (age 40 years or less) were compared with older patients (age more than 40 years).

Results

There were total of 114 patients treated during the study period. The mean age was 59.2 ±14.3 years with age range of 22 to 87 years. Eighteen patients (15.8%) were less than 40 years of age and 96 patients (84.2%) were more than 40 years. Male to female ratio in younger patients was 1:1.3 where as the ratio in older patients was 1:0.6. In younger age group 14 patients (77.8%) had poorly differentiated adenocarcinoma which was 48% in older age group (p < 0.01). 56% of younger patients had stage IV disease at presentation and curative surgery was not possible. In older patients 43% had stage IV disease at presentation. Palliative surgery for gastric outlet obstruction or bleeding from the tumor was done on 27% of younger patients and 18% of older patients.

Conclusion

Gastric cancer is usually considered as a disease of elderly population but it can occur in younger patients also. This cancer in young has unique characters like female predominance, unfavorable tumor biology, advanced stage at presentation. There should be high index of suspicion of gastric cancer even in young patients.